Phage Therapy: A Practical Approach

Description

This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail. This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies. Front Matter ....Pages i-xv Front Matter ....Pages 1-1 Production of Phage Therapeutics and Formulations: Innovative Approaches (Maia Merabishvili, Jean-Paul Pirnay, Kilian Vogele, Danish J. Malik)....Pages 3-41 Phage Pharmacokinetics: Relationship with Administration Route (Shigenobu Matsuzaki, Jumpei Uchiyama)....Pages 43-57 Bacterial Resistance to Phage and Its Impact on Clinical Therapy (Shawna McCallin, Frank Oechslin)....Pages 59-88 Front Matter ....Pages 89-89 Phage Interaction with the Mammalian Immune System (Jonas D. Van Belleghem, Krystyna Dąbrowska, Mario Vaneechoutte, Jeremy J. Barr)....Pages 91-122 Humoral Immune Response to Phage-Based Therapeutics (Maciej Żaczek, Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska, Ryszard Międzybrodzki, Wojciech Fortuna, Paweł Rogóż et al.)....Pages 123-143 Front Matter ....Pages 145-145 How to Achieve a Good Phage Therapy Clinical Trial? (Jérôme Gabard, Patrick Jault)....Pages 147-168 Treatment and Prevention of Bacterial Infections Using Bacteriophages: Perspectives on the Renewed Interest in the United States (Randall Kincaid)....Pages 169-187 Phage Therapy in Orthopaedic Implant-Associated Infections (Paweł Rogóż, Derek F. Amanatullah, Ryszard Międzybrodzki, Robert Manasherob, Nina V. Tikunova, Beata Weber-Dąbrowska et al.)....Pages 189-211 The Use of Bacteriophages in Animal Health and Food Protection (Katarzyna Kosznik-Kwaśnicka, Gracja Topka, Aleksandra Dydecka, Agnieszka Necel, Bożena Nejman-Faleńczyk, Sylwia Bloch et al.)....Pages 213-256 Combining Bacteriophages with Other Antibacterial Agents to Combat Bacteria (Petar Knezevic, Verica Aleksic Sabo)....Pages 257-293 Phage Therapy of Infectious Biofilms: Challenges and Strategies (Luís D. R. Melo, Diana Priscila Pires, Rodrigo Monteiro, Joana Azeredo)....Pages 295-313 Front Matter ....Pages 315-315 Phage Lysins: Novel Alternative to Antibiotics (Vincent A. Fischetti)....Pages 317-334 Front Matter ....Pages 335-335 Regulatory Considerations for Bacteriophage Therapy Products (Roger D. Plaut, Scott Stibitz)....Pages 337-349 Developing Phages into Medicines for Europe (Eric Pelfrene, Zigmars Sebris, Marco Cavaleri)....Pages 351-361 Phage Therapy in Europe: Regulatory and Intellectual Property Protection Issues (Daniel De Vos, Gilbert Verbeken, Johan Quintens, Jean-Paul Pirnay)....Pages 363-377 Ethics of Phage Therapy (Jan Borysowski, Andrzej Górski)....Pages 379-385