Chromosome Translocation

Description

This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases. The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation. It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases. Front Matter ....Pages i-v Historical and Clinical Perspectives on Chromosomal Translocations (Ellen S. Wilch, Cynthia C. Morton)....Pages 1-14 Induction of Chromosomal Translocations with CRISPR-Cas9 and Other Nucleases: Understanding the Repair Mechanisms That Give Rise to Translocations (Erika Brunet, Maria Jasin)....Pages 15-25 Dynamics of Double-Strand Breaks: Implications for the Formation of Chromosome Translocations (Henrike Johanna Gothe, Vera Minneker, Vassilis Roukos)....Pages 27-38 The CRISPR/Cas9 System as a Tool to Engineer Chromosomal Translocation In Vivo (Taek-Chin Cheong, Rafael B. Blasco, Roberto Chiarle)....Pages 39-48 Generation of Genomic Alteration from Cytidine Deamination (Xiaojing Liu, Fei-Long Meng)....Pages 49-64 The Role for the DSB Response Pathway in Regulating Chromosome Translocations (Rajib Ghosh, Debamitra Das, Sonia Franco)....Pages 65-87 Telomeres and Chromosomal Translocations (Duncan M. Baird, Eric A. Hendrickson)....Pages 89-112 3D Genome Organization Influences the Chromosome Translocation Pattern (Rachel Patton McCord, Adayabalam Balajee)....Pages 113-133 The Role of Chromosome Deletions in Human Cancers (Mei Chen, Yi Yang, Yu Liu, Chong Chen)....Pages 135-148 Processing-Challenges Generated by Clusters of DNA Double-Strand Breaks Underpin Increased Effectiveness of High-LET Radiation and Chromothripsis (Emil Mladenov, Janapriya Saha, George Iliakis)....Pages 149-168