Retroviral Immunology: Immune Response and Restoration

Description

Over the last decade much has been written about HIV and AIDS, although there has been surprisingly very little written on the immunology of retroviral infections, in general, and on HIV in particular. In Retroviral Immunology: Immune Response and Restoration, world-renowned authorities address the most important aspects of the immunology of retroviruses, namely, immune response, genetic and virologic factors modulating the response, and the HIV-specific humoral and cell-mediated responses. In addition to the basic concepts of immune restoration, key topics covered include immune restoration after antiviral therapy-a highly important subject to the thousands of clinicians who deal with the problem on a daily basis-and vaccine-induced immune response. Up-to-date and authoritative, Retroviral Immunology: Immune Response and Restoration provides a much-needed critical synthesis of both the experimental and clinical aspects of retroviral infections, and lays the groundwork for developing effective restoration strategies for the many immune-compromised HIV and AIDS patients who suffer fatal opportunistic infections. Front Matter....Pages i-x Epidemiological and Immunological Implications of the Global Variability of HIV-1....Pages 1-32 Role of Chemokines and Their Receptors in the Pathogenesis of HIV Infection....Pages 33-51 Cytokines and Chemokines in HIV Infection....Pages 53-78 Development and Reconstitution of T-Lymphoid Immunity....Pages 79-107 HIV Gene Products as Manipulators of the Immune System....Pages 109-123 Immune Response to Murine and Feline Retroviruses....Pages 125-157 Immune Response to HTLV-I and HTLV-II....Pages 159-190 HIV-Specific Neutralizing Antibodies....Pages 191-211 Cytotoxic T-Cell Responses in Acute and Chronic HIV-1 Infection....Pages 213-235 Characterization of the HIV-1-Specific T-Helper Cell Response....Pages 237-247 Immune Responses to Nonhuman Primate Lentiviruses....Pages 249-279 Intrahost Selective Pressure and HIV-1 Heterogeneity During Progression to AIDS....Pages 281-296 Polymorphism in HLA and Other Elements of the Class I and II Response Pathways....Pages 297-316 Immunologic Approaches to the Therapy of Patients with HIV Infection....Pages 317-329 Back Matter....Pages 331-336