Molecular Cardiology in Clinical Practice

Description

Cardiology is an area of great recent triumphs in pharmacological and surgical treatment, yet cardiovascular disease remains the leading cause of death and disability in the industrialized world. Coronary disease, heart failure, stroke and sudden arrhythmic cardiac death challenge both medical practitioners and scientists. With the dawning of the new `molecular' era, there is an awakened hope that a more fundamental understanding of biologic processes may eventually lead to new progress in the prevention and treatment of these persistent and seemingly intransigent problems. Molecular Cardiology in Clinical Practice brings together an outstanding panel of experts in cardiovascular disease who have been at the forefront of the application of molecular medicine to cardiology. Its intent is to help bridge the gap between modern medical practice and modern science, in the belief that an understanding of basic principles can lead to new insight into the problems of cardiac patients. Front Matter....Pages i-xv Introduction to Molecular Medicine: A Contemporary View of Heart Failure....Pages 1-27 Molecular Mechanisms of Myocardial Remodeling....Pages 29-42 Pathophysiology of Heart Failure in Regurgitant Valvular Diseases: Relation to Ventricular Dysfunction and Clinical Debility....Pages 43-56 Coronary Atherothrombosis: Pathophysiology and Clinical Implications....Pages 57-75 Prevention of Atherosclerosis: Endothelial Function, Cholesterol, and Antioxidants....Pages 77-106 Physiologic and Pathophysiologic Effects of Angiotensin in the Heart and Vessel Wall....Pages 107-124 Regulation of Inflammation by Fas Ligand Expression on the Vascular Endothelium....Pages 125-141 Molecular Mechanisms of Platelet Activation and Inhibition....Pages 143-167 Molecular Determinats of the T Wave....Pages 169-186 Sexual Dimorphism in Cardiovascular Disease....Pages 187-217 Back Matter....Pages 219-226