ENGLISH

Protein Structure, Stability, and Folding

By Kenneth P. Murphy (auth.) , Kenneth P. Murphy (eds.)

Book information

Publisher
Humana Press
Year
2001
ISBN
9780896036826, 0-89603682-0
DOI
10.1385/1592591930
Open Library ID
OL17009075M
Language
english
Format
PDF
Filesize
1 MB (1367928 bytes)
Series
Methods in Molecular Biology 168
Edition
1
Pages
252\263
Library
mexmat
Time added
2009-07-20 03:45:11
Biochemistrygeneral

Description

With the huge increase in available data on the DNA sequences of proteins, there is a growing need to understand and characterize how proteins fold into their biologically active native states and the basis for the stability of these states. In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating aspects of protein stability and dynamics from knowledge of the structure, for calculating conformational entropy, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of this complex area by detailing many of the major innovative techniques in use today.

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