Theoretical and Applied Aspects of Systems Biology

Description

This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases. This book presents several chapters written by renowned experts in the field. Some topics discussed in depth in this book include: computational modeling of multiresistant bacteria, systems biology of cancer, systems immunology, networks in systems biology. Front Matter ....Pages i-xviii Front Matter ....Pages 1-1 Bio-modeling Using Petri Nets: A Computational Approach (Rafael V. Carvalho, Fons J. Verbeek, Clarimar J. Coelho)....Pages 3-26 Modeling Gene Transcriptional Regulation: A Primer (Marcelo Trindade dos Santos, Ana Paula Barbosa do Nascimento, Fernando Medeiros Filho, Fabricio Alves Barbosa da Silva)....Pages 27-39 Cellular Reprogramming (Domenico Sgariglia, Alessandra Jordano Conforte, Luis Alfredo Vidal de Carvalho, Nicolas Carels, Fabricio Alves Barbosa da Silva)....Pages 41-55 Metabolic Models: From DNA to Physiology (and Back) (Marcio Argollo de Menezes)....Pages 57-69 Analysis Methods for Shotgun Metagenomics (Stephen Woloszynek, Zhengqiao Zhao, Gregory Ditzler, Jacob R. Price, Erin R. Reichenberger, Yemin Lan et al.)....Pages 71-112 ANOCVA: A Nonparametric Statistical Test to Compare Clustering Structures (Alexandre Galvão Patriota, Maciel Calebe Vidal, Davi Augusto Caetano de Jesus, André Fujita)....Pages 113-125 Front Matter ....Pages 127-127 Modeling of Cellular Systems: Application in Stem Cell Research and Computational Disease Modeling (Muhammad Ali, Antonio del Sol)....Pages 129-138 Using Thermodynamic Functions as an Organizing Principle in Cancer Biology (Edward Rietman, Jack A. Tuszynski)....Pages 139-157 Systems Immunology (Melissa Lever, Thiago C. Hirata, Pedro S. T. Russo, Helder I. Nakaya)....Pages 159-173 The Challenge of Translating System Biology into Targeted Therapy of Cancer (Alessandra Jordano Conforte, Milena Magalhães, Tatiana Martins Tilli, Fabricio Alves Barbosa da Silva, Nicolas Carels)....Pages 175-194 Computational Modeling of Multidrug-Resistant Bacteria (Fabricio Alves Barbosa da Silva, Fernando Medeiros Filho, Thiago Castanheira Merigueti, Thiago Giannini, Rafaela Brum, Laura Machado de Faria et al.)....Pages 195-220 System Biology to Access Target Relevance in the Research and Development of Molecular Inhibitors (Larissa Catharina, Marcio Argollo de Menezes, Nicolas Carels)....Pages 221-242 Mathematical-Computational Modeling in Behavior’s Study of Repetitive Discharge Neuronal Circuits (Celia Martins Cortez, Maria Clicia Stelling de Castro, Vanessa de Freitas Rodrigues, Camila Andrade Kalil, Dilson Silva)....Pages 243-259