Brain-Bladder Axis in Tissue Growth and Remodelling

Description

Applying the general deterministic approach of systems computational biology, the monograph considers questions related to the biomechanics of the human urinary bladder in conjunction with the peripheral and central nervous systems. The step-by-step development of mathematical models of separate structural elements and their assembly into a unique self-regulatory system offers, for the first time, a holistic overview and allows the investigation of the dynamics of the lower urinary tract system at its hierarchical levels. This book provides a coherent description and explanation for intertwined intracellular pathways in terms of spatiotemporal, whole body, tractable representations which are supported by numerous computational simulations. Key Features It reconstructs accurately the cytoarchitecture and morphofunctional relationships between the elements of the central nervous (brain) and genitourinary (urinary bladder system).Offers for the first time a both quantitative and qualitative, assessment of the neurohormonal and mechanobiological processes involved in the process.Provides a comprehensive description for intertwined regulatory pathways in terms of spatiotemporal dynamic representations.Encourages the reader to develop and apply a unique holistic approach to solving complex biomedical problems in the area of growth and remodeling of the urinary bladder through application of modern methods of computational biology. PRELIMS.pdf Preface Author biographies Roustem N Miftahof Christian J Cyron Acronyms CH001.pdf Chapter 1 Anatomical and morphological preliminaries 1.1 Overview of the urinary bladder 1.2 Detrusor muscle 1.3 ‘Pacemakers’ 1.4 Mechanosensation 1.5 Afferent signalling 1.6 Neuronal assemblies in the hypothalamus and adenohypophysis 1.6.1 Periventricular nucleus 1.6.2 Arcuate nucleus-median eminence complex 1.6.3 Adenohypophysis (somatotrpohs) References CH002.pdf Chapter 2 Continual models of the bladder tissue 2.1 Single-phase models 2.2 Multiphase models References CH003.pdf Chapter 3 Models of the urinary bladder 3.1 The bladder as shell structure 3.2 The bladder as soft bioshell 3.2.1 General postulates 3.2.2 Governing equations in general curvilinear coordinates Remarks 3.2.3 Electromyogenic phenomenon 3.2.4 Electromechanical coupling 3.2.5 Mechanosensory element 3.2.6 Problem closure References CH004.pdf Chapter 4 Signalling mechanisms 4.1 L-Glutamate 4.2 GABA 4.3 Glycine 4.4 Somatostatin 4.5 Growth hormone releasing hormone 4.6 Ghrelin 4.7 Growth hormone 4.8 Insulin-like growth factor-1 4.9 Myogenesis 4.10 Collagenesis References CH005.pdf Chapter 5 Modelling the (intra)hypothalamic–pituitary axis 5.1 Signal transduction 5.2 Protein-tyrosine kinase receptor signalling 5.3 Gene expression 5.4 Hormonal interactions References CH006.pdf Chapter 6 Growth and remodelling 6.1 Biological preliminaries 6.2 Continuum mechanics growth and remodelling models 6.2.1 General postulates 6.2.2 Kinematic growth model 6.2.3 Constrained mixture theory 6.2.4 A homogenised constrained mixture model References CH007.pdf Chapter 7 Brain–bladder axis in tissue growth and remodelling 7.1 The architecture of the BBA 7.2 Mathematical formulation of the BBA 7.3 An Achilles’ heel 7.4 Simulation results References CH008.pdf Chapter 8 What is to follow? 8.1 Making a model reliable 8.2 Model expansions in biomedicine 8.3 Implementations in engineering References APP1.pdf Chapter A.1 Governing equations in orthogonal Cartesian coordinates A.2 Governing equations in cylindrical coordinates APP2.pdf Chapter B.1 cAMP-dependent pathway B.2 PLC-dependent pathway B.3 PI3K/PkB pathway B.4 cGMP-dependent PkG B.5 RAS/MAPK pathway References APP3.pdf Chapter C.1 Endoplasmic reticulum and Ca2+ turnover References APP4.pdf Chapter