Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations

Description

Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits. Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses. Front Matter....Pages i-xviii Front Matter....Pages 1-1 Aspects of the History and Nomenclature of Amyloid and Amyloidosis....Pages 3-8 Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis....Pages 9-29 AA Amyloidosis....Pages 31-51 The Hereditary Amyloidoses....Pages 53-67 Dialysis-Associated Amyloidosis....Pages 69-80 Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System....Pages 81-103 Cerebrovascular Amyloidoses....Pages 105-110 Front Matter....Pages 111-111 Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Materials in the Differential Diagnosis of Amyloidosis....Pages 113-127 Light/Heavy Chain Deposition Disease as a Systemic Disorder....Pages 129-141 Non-Randall Glomerulonephritis with Non-organized Monoclonal Ig Deposits....Pages 143-153 Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond....Pages 155-163 Front Matter....Pages 165-165 Diagnosis of Amyloid Using Congo Red....Pages 167-173 Diagnosis of Minimal Amyloid Deposits Using the Congo Red Fluorescence Method: A Review....Pages 175-185 Thioflavin T Stain: An Easier and More Sensitive Method for Amyloid Detection....Pages 187-189 Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis....Pages 191-207 Generic Diagnosis of Amyloid: A Summary of Current Recommendations and the Editorial Comments on Chaps. 12–15....Pages 209-217 Routine Use of Amyloid Typing on Formalin-Fixed Paraffin Sections from 626 Patients by Immunohistochemistry....Pages 219-229 Amyloid Typing: Experience from a Large Referral Centre....Pages 231-238 Options for Amyloid Typing in Renal Pathology: The Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations for Immunohistochemistry (Chaps. 17–19)....Pages 239-248 Amyloid Typing: Immunoelectron Microscopy....Pages 249-260 Front Matter....Pages 165-165 Classification of Amyloidosis by Mass Spectrometry-Based Proteomics....Pages 261-272 Front Matter....Pages 273-273 Laboratory Support for Diagnosis of Amyloidosis....Pages 275-282 Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias....Pages 283-290 Laboratory Methods for the Diagnosis of Hereditary Amyloidoses....Pages 291-302 Front Matter....Pages 303-303 Amyloidoses of the Kidney and Genitourinary Tract....Pages 305-318 Cardiac Amyloidosis....Pages 319-337 Amyloidosis of the Gastrointestinal Tract and Liver....Pages 339-360 Peripheral Nerve Amyloidosis....Pages 361-374 Front Matter....Pages 375-375 Clinical and Pathologic Issues in Patients with Amyloidosis: Practical Comments Regarding Diagnosis, Therapy, and Solid Organ Transplantation....Pages 377-391 Emerging Therapies for Amyloidosis....Pages 393-397 Modern Therapies in AA Amyloidosis....Pages 399-403 Medicolegal Issues of Amyloidosis....Pages 405-412 Amyloidosis from the Patient’s Perspective....Pages 413-417 Back Matter....Pages 419-425