Imaging Dementia. Essentials for Clinical Practice

Description

Acknowledgments Introduction Contents 1: Alzheimer’s Disease 1.1 Clinicopathological Findings 1.1.1 Epidemiology and Risk Factors 1.1.2 Etiology and Pathophysiology 1.1.3 Clinical Picture: The AD Continuum 1.1.4 Diagnostic Criteria and Diagnostic Algorithm 1.2 Neuroimaging 1.2.1 Conventional Structural Neuroimaging 1.2.1.1 Computed Tomography 1.2.1.2 Structural MRI 1.2.2 Molecular Imaging 1.2.2.1 SPECT and FDG-PET 1.2.2.2 Amyloid Imaging 1.2.2.3 Tau Imaging 1.2.3 Advanced MRI Techniques 1.2.3.1 Diffusion Tensor MRI 1.2.3.2 Functional MRI 1.3 Clinical Case #1 1.4 Clinical Case #2 References 2: Vascular Cognitive Impairment 2.1 Clinicopathological Findings 2.1.1 Epidemiology 2.1.2 Etiology and Pathophysiology 2.1.3 Risk Factors 2.1.4 Clinical Picture 2.1.5 Diagnostic Criteria 2.2 Neuroimaging 2.2.1 Conventional Neuroimaging Techniques 2.2.1.1 Computed Tomography 2.2.1.2 Magnetic Resonance Imaging 2.2.2 Structural Imaging Correlates of VCI 2.2.2.1 Large Vessel Disease (Large Ischemic Lesions) 2.2.2.2 Small Vessel Disease White Matter Hyperintensities of Presumed Vascular Origin Lacunes Perivascular Spaces Cerebral Microbleeds Brain Atrophy 2.2.3 Molecular Imaging 2.2.4 Advanced MRI Techniques 2.2.4.1 Diffusion Tensor MRI 2.2.4.2 Functional MRI 2.3 Clinical Case #1 2.4 Clinical Case #2 References 3: Frontotemporal Lobar Degeneration 3.1 Clinicopathological Findings 3.1.1 The Spectrum of FTLD Clinical Presentations 3.1.2 Pathology and Genetics 3.2 Neuroimaging 3.2.1 Structural Neuroimaging 3.2.1.1 Behavioral Variant of Frontotemporal Dementia 3.2.1.2 Primary Progressive Aphasia 3.2.2 Molecular Imaging 3.2.2.1 SPECT and PET Imaging 3.2.2.2 Amyloid PET 3.2.2.3 Tau PET 3.2.3 Advanced MRI Techniques 3.2.3.1 Diffusion Tensor MRI 3.2.3.2 Functional MRI 3.2.4 Neuroimaging in Presymptomatic FTLD 3.3 Clinical Case #1 3.4 Clinical Case #2 References 4: Parkinsonian Dementias 4.1 Parkinson’s Disease and Dementia with Lewy Bodies 4.1.1 Clinicopathological Findings 4.1.2 Neuroimaging 4.1.2.1 Structural Neuroimaging Techniques 4.1.2.2 Molecular Imaging SPECT PET 4.1.2.3 Advanced MRI Techniques Diffusion Tensor MRI Functional MRI 4.2 Atypical Parkinsonisms 4.2.1 Clinicopathological Findings 4.2.1.1 PSP Syndrome 4.2.1.2 Corticobasal Syndrome 4.2.1.3 Multiple System Atrophy 4.2.2 Neuroimaging 4.2.2.1 Structural Neuroimaging 4.2.2.2 Molecular Imaging 4.2.2.3 Advanced MRI Techniques Diffusion Tensor MRI Functional MRI 4.3 Clinical Case #1 4.4 Clinical Case #2 References 5: Rapidly Progressive Dementias 5.1 Clinicopathological Findings 5.1.1 Diagnostic Workup 5.1.2 Prion Diseases 5.1.2.1 Epidemiology and Classification 5.1.2.2 Clinical Features 5.1.2.3 Diagnosis 5.2 Neuroimaging 5.2.1 Structural Neuroimaging 5.2.2 Molecular Imaging 5.2.3 Advanced MRI Techniques 5.3 Clinical Case #1 5.4 Clinical Case #2 References