Drug Delivery: An Integrated Clinical and Engineering Approach

Description

Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery. Content: An introduction of key concepts in drug delivery / Steven Cooperberg, Mahyar Pourriahi, Jonathan Daich, Aaron Richler, Pablo Gurman, Noel M. Elman, and Yitzhak Rosen -- An introduction to pharmacokinetics : from conventional to advanced systemic drug delivery systems / Alan Talevi, Luis Bruno Blanch, and Guillermo R. Castro -- Transporters and enzymes targeted prodrugs for improved oral drug delivery / Arik Dahan and Shimon Ben-Shabat -- Gastroretentive delivery-physicochemical, biopharmaceutical, technological, and regulatory considerations / Yuvraj Singh, Vivek K. Pawar, Mohini Chaurasia, Manish K. Chourasia -- Invasive vs. non-invasive delivery of insulin / Sandra Soares, Ana Costa, Pedro Fonte, and Bruno Sarmento -- The artificial pancreas / Howard Zisser, Jennifer Lane, Joseph Shivers -- Micro/nano devices for drug delivery / R. Sheybani and E. Meng -- Microneedle-mediated vaccines / Ryan F. Donnelly, Maelíosa T.C. McCrudden, Sharifa Al-Zahrani, and Steven J. Fallows -- Application of nanoparticle tracking analysis in drug delivery / Matthew Wright -- Microsponges for drug delivery / Rishabh Srivastava -- Chitosan for advancing drug delivery / Sankay K. Jain and Satish Shilpi. Gene delivery by electroporation / Julie Gehl -- Drug delivery systems for infectious diseases / Maximiliano L. Cacicedo, Germán A. Islan, Pablo Gurman, and Guillermo R. Castro -- Nanotechnology in drug delivery to chronic inflammatory diseases / Mazen El-Hammadi and José L. Arias -- Intrathecal drug delivery / SriKrishna Chandran -- Cancer stem cell drug delivery / Masturah Bte Mohd Abdul Rashid, Lissa Nurrul Abdullah, Tan Boon Toh, Edward Kai-Hua Chow -- Cardiac drug delivery / Paula Díaz-Herráez, Simón Pascual-Gil de Gómez, Elisa Garbayo, Teresa Simón-Yarza, Felipe Prósper, and María J. Blanco-Prieto -- Current developments in nano-therapeutics for airway diseases / Indrajit Roy, Ridhima Juneja, Komal Sethi, and Neeraj Vij -- Intravitreal drug delivery / Omar Saleh, Mark Ihnen, and Shlomit Schaal -- Drug delivery in obstetrics and gynecology / David Shveiky, Yael Hants, and Sarit Helman -- Drug delivery systems : a regulatory perspective / Pablo Gurman, Noel M. Elman, and Yitzhak Rosen.