Peptide Materials: From Nanostructures to Applications

Description

Peptides are the building blocks of the natural world; with varied sequences and structures, they enrich materials producing more complex shapes, scaffolds and chemical properties with tailorable functionality. Essentially based on self-assembly and self-organization and mimicking the strategies that occur in Nature, peptide materials have been developed to accomplish certain functions such as the creation of specific secondary structures (a- or 310-helices, b-turns, b-sheets, coiled coils) or biocompatible surfaces with predetermined properties. They also play a key role in the generation of hybrid materials e.g. as peptide-inorganic biomineralized systems and peptide/polymer conjugates, producing smart materials for imaging, bioelectronics, biosensing and molecular recognition applications.Organized into four sections, the book covers the fundamentals of peptide materials, peptide nanostructures, peptide conjugates and hybrid nanomaterials, and applications with chapters including:Properties of peptide scaffolds in solution and on solid substratesNanostructures, peptide assembly, and peptide nanostructure designSoft spherical structures obtained from amphiphilic peptides and peptide-polymer hybridsFunctionalization of carbon nanotubes with peptidesAdsorption of peptides on metal and oxide surfacesPeptide applications including tissue engineering, molecular switches, peptide drugs and drug deliveryPeptide Materials: From Nanostructures to Applications gives a truly interdisciplinary review, and should appeal to graduate students and researchers in the fields of materials science, nanotechnology, biomedicine and engineering as well as researchers in biomaterials and bio-inspired smart materials.Content: Chapter 1 Physics of Peptide Nanostructures and Their Nanotechnology Applications (pages 1–37): Nadav Amdursky, Peter Beker and Gil RosenmanChapter 2 Chemistry of Peptide Materials (pages 39–63): Fernando Formaggio, Alessandro Moretto, Marco Crisma and Claudio TonioloChapter 3 Conformational Aspects and Molecular Dynamics Simulations of Peptide Hybrid Materials (pages 65–103): Carlos Aleman, Oscar Bertran, Jordi Casanovas, Juan Torras, Guillermo Revilla?Lopez and David ZanuyChapter 4 Peptronics (pages 105–147): Emanuela Gatto and Mariano VenanziChapter 5 Molecular Architecture with Peptide Assembling for Nanomaterials (pages 149–170): Shunsaku Kimura and Motoki UedaChapter 6 Principles of Shape?Driven Nanostructure Design via Self?Assembly of Protein Building Blocks (pages 171–189): Idit Buch, Chung?Jung Tsai, Carlos Aleman and Ruth NussinovChapter 7 Peptide?Based Soft Spherical Structures (pages 191–216): K. Vijaya Krishna, Nidhi Gour and Sandeep VermaChapter 8 Peptide?Based Carbon Nanotube Dispersal Agents (pages 217–245): Anton S. Klimenko and Gregg R. DieckmannChapter 9 Nanosized Vectors for Transfection Assembled from Peptides and Nucleic Acids (pages 247–264): Burkhard BechingerChapter 10 Properties of Disubstituted Ferrocene–Peptide Conjugates (pages 265–287): Sanela Martic, Samaneh Beheshti and Heinz?Bernhard KraatzChapter 11 Mechanisms of Adsorption of Short Peptides on Metal and Oxide Surfaces (pages 289–311): Vincent Humblot, Jessem Landoulsi and Claire?Marie PradierChapter 12 Bioactive Rosette Nanotubes for Bone Tissue Engineering and Drug Delivery (pages 313–357): Rachel L. Beingessner, Alaaeddin Alsbaiee, Baljit Singh, Thomas J. Webster and Hicham FenniriChapter 13 Peptide Secondary Structures as Molecular Switches (pages 359–384): Fernando Formaggio, Alessandro Moretto, Marco Crisma and Claudio TonioloChapter 14 Peptide Nanostructured Conjugates for Therapeutics (pages 385–415): Yves Frere, Louis Danicher and Sylviane MullerChapter 15 Identification and Application of Polymer?Binding Peptides (pages 417–433): Toshiki Sawada and Takeshi Serizawa