Store-Operated Ca2+ Entry (SOCE) Pathways: Emerging Signaling Concepts in Human (Patho)physiology

Description

This second edition of the book on Store-operated Ca2+ Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years. The crystal structure of the Ca2+ signaling core complex is described which adds to a new understanding of the molecular interactions involved. Each chapter has been revised and extended. The book retains its interdisciplinary approach and supplies biochemists, cell biologists and biophysicists as well as clinicians in immunology, neurology and cardiology with valuable information on Ca2+ signaling mechanisms, functions, dysfunctions and their consequences. Front Matter ....Pages i-xxix Front Matter ....Pages 1-1 Introduction (James W. Putney)....Pages 3-13 The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex (Jinhui Zhu, Qingping Feng, Peter B. Stathopulos)....Pages 15-38 The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel (Aparna Gudlur, Patrick G. Hogan)....Pages 39-57 The STIM-Orai Pathway: The Interactions Between STIM and Orai (Marc Fahrner, Rainer Schindl, Martin Muik, Isabella Derler, Christoph Romanin)....Pages 59-81 The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry (Robert M. Nwokonko, Xiangyu Cai, Natalia A. Loktionova, Youjun Wang, Yandong Zhou, Donald L. Gill)....Pages 83-98 The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications (Barbara A. Niemeyer)....Pages 99-116 The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels (Guolin Ma, Shufan Wen, Yun Huang, Yubin Zhou)....Pages 117-138 STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes (Dora Bodnar, Woo Young Chung, Dongki Yang, Jeong Hee Hong, Archana Jha, Shmuel Muallem)....Pages 139-157 STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function (Hwei Ling Ong, Indu S. Ambudkar)....Pages 159-188 STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex (Jonathan Pacheco, Luis Vaca)....Pages 189-210 Front Matter ....Pages 211-211 Introduction (Alexei V. Tepikin)....Pages 213-216 New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE (Hayley Dingsdale, Emmanuel Okeke, Lee Haynes, Gyorgy Lur, Alexei V. Tepikin)....Pages 217-237 New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores (Alexis Bavencoffe, Michael Xi Zhu, Jin-bin Tian)....Pages 239-255 The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and Mitochondria (András Spät, Gergö Szanda)....Pages 257-275 The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling Hubs Sustaining Store-Operated Ca2+ Entry (Nicolas Demaurex, Daniele Guido)....Pages 277-296 The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry (Roland Malli, Wolfgang F. Graier)....Pages 297-319 Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling (Nicola Fameli, A. Mark Evans, Cornelis van Breemen)....Pages 321-342 Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells (Lothar A. Blatter)....Pages 343-361 Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes (Martin D. Bootman, Katja Rietdorf)....Pages 363-387 Front Matter ....Pages 389-389 Introduction: Overview of the Pathophysiological Implications of Store-Operated Calcium Entry in Mammalian Cells (Juan A. Rosado)....Pages 391-395 Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes (Sonal Srikanth, Jin Seok Woo, Zuoming Sun, Yousang Gwack)....Pages 397-424 Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders (Jyoti Tanwar, Mohamed Trebak, Rajender K. Motiani)....Pages 425-452 Cardiovascular and Hemostatic Disorders: SOCE and Ca2+ Handling in Platelet Dysfunction (Jose J. Lopez, Gines M. Salido, Juan A. Rosado)....Pages 453-472 Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention (Klaus Groschner, Niroj Shrestha, Nicola Fameli)....Pages 473-503 Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology (Petra Eder)....Pages 505-521 Cardiac Remodeling and Disease: Current Understanding of STIM1/Orai1-Mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology (Fiona Bartoli, Jessica Sabourin)....Pages 523-534 Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function (Sunitha Bollimuntha, Biswaranjan Pani, Brij B. Singh)....Pages 535-556 Neurological and Motor Disorders: TRPC in the Skeletal Muscle (Sophie Saüc, Maud Frieden)....Pages 557-575 Fertility: Store-Operated Ca2+ Entry in Germ Cells: Role in Egg Activation (Zoltan Machaty, Chunmin Wang, Kiho Lee, Lu Zhang)....Pages 577-593 Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease (Eunüs S. Ali, Grigori Y. Rychkov, Greg J. Barritt)....Pages 595-621 Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion (Abigaël Ritaine, George Shapovalov, Natalia Prevarskaya)....Pages 623-637 Back Matter ....Pages 639-645