ENGLISH

Methods in microarray normalization

By Phillip Stafford

Book information

Publisher
CRC Press
Year
2008
ISBN
9781420052787, 1420052780
LCC
QP624.5.D726 M47 2008
Open Library ID
OL11816614M
Language
english
Format
PDF
Filesize
24 MB (24839734 bytes)
Series
Drug discovery series 10
Pages
322\322
Library
Kingdwarf
Time added
2010-01-07 06:59:20

Description

Scientists can use molecular profiling microarrays to compare healthy cells with their diseased counterparts and develop gene-specific treatments. Finding the best way to interpret original profiling data into accurate trends, however, continues to drive the development of normalization algorithms and software tools. Methods in Microarray Normalization compiles the most useful and novel techniques for the first time into a single, organized source. Experts in the field provide a diverse view of the mathematical processes that are important in normalizing data and avoiding inherent systematic biases. They also review useful software, including discussions on key algorithms, comparative data, and download locations. The book discusses the use of early normalization techniques for new profiling methods and includes strategies for assessing the utility of various normalization algorithms. It presents the latest microarray innovations from companies such as Agilent, Affymetrix, and GeneGo as well as new normalization methods for protein and CGH arrays, many of which are applicable for antibody, microRNA, methylation, and siRNA arrays. Methods in Microarray Normalization provides scientists with a complete resource on the most effective tools available for maximizing microarray data in biochemical research.

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