Ciba Foundation Symposium 68 - Enzyme Defects and Immune Dysfunction
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Content: Chapter 1 Chairman's Introduction (pages 1–2): D. W. MartinChapter 2 Adenosine Deaminase and Purine Nucleoside Phosphorylase Deficiency: How They Were Discovered and What They May Mean (pages 3–18): Eloise R. GiblettChapter 3 Buridan's Ass: One Man's View of the Immune System (pages 19–34): Jan KleinChapter 4 Clinical Delineation of Adenosine Deaminase Deficiency (pages 35–54): Rochelle HirschhornChapter 5 Immunological Aberrations in Purine Nucleoside Phosphorylase Deficiencies (pages 55–75): Arthur J. AmmannChapter 6 Immunodeficiency Due to Transcobalamin II Deficiency (pages 77–99): W. H. Hitzig, Marijke Frater?Schroder and R. SegerChapter 7 Nucleotide Metabolism in Cultured T Cells and in Cells of Patients Deficient in Adenosine Deaminase and Purine Nucleoside Phosphorylase (pages 101–114): Amos Cohen, Lorraine J. Gudas, Buddy Ullman and David W. MartinChapter 8 Deoxyribonucleoside Toxicity in Adenosine Deaminase and Purine Nucleoside Phosphorylase Deficiency: Implications for the Development of New Immunosuppressive Agents (pages 115–133): Dennis A. Carson and Jonathan KayeChapter 9 Ecto 5??Nucleotidase Deficiency in Primary Hypogammaglobulinaemia (pages 135–164): A. D. B. Webster, M. Rowe, S. M. Johnson, G. L. Asherson and A. HarknessChapter 10 Allosteric Regulation of Calf Thymusribonucleotide Reductase (pages 165–175): S. Eriksson and L. ThelanderChapter 11 Adenosine Deaminase: Characteristics of the Normal and Mutant Forms of the Human Enzyme (pages 177–191): Peter E. Daddona and William N. KelleyChapter 12 Purine Nucleoside Phosphorylase: The Normal Enzyme and Structural Alterations in Immunodeficiency Disease (pages 193–205): Irving H. Fox, Catherine M. Andres, Janice Kaminska and Robert L. WortmannChapter 13 Purine Nucleoside Phosphorylase: Immunodetection and Characterization of the Human Enzyme (pages 207–211): Gabrielle H. ReemChapter 14 Enzyme Replacement and Other Biochemical Approaches to the Therapy of Adenosine Deaminase Deficiency (pages 213–230): Stephen H. PolmarChapter 15 An Approach to the Restoration of T Cell Function in a Purine Nucleoside Phosphorylase Deficient Patient (pages 231–253): B. J. M. Zegers, J. W. Stoop, G. E. J. Staal and S. K. WadmanChapter 16 Purine Metabolism in Adenosine Deaminase Deficiency (pages 255–279): H. Anne Simmonds, A. Sahota, C. F. Potter, D. Perrett, K. Hugh?Jones and J. G. Watson
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