ENGLISH

Advanced Delivery and Therapeutic Applications of RNAi

Book information

Year
2013
ISBN
9781119976868, 9781118610749
DOI
10.1002/9781118610749
Language
english
Format
PDF
Filesize
18 MB (18616254 bytes)
Pages
534\534
Orientation
yes
Paginated
yes
Scanned
landscape
Time added
2013-08-01 04:00:00

Description

RNA interference (RNAi) is a process in living cells whereby small double stranded RNA interferes with the expression of specific genes with complementary nucleotide sequence. Like many nucleic acid-based therapies, RNAi has great potential in treating various life-threatening diseases. However, the poor stability and cellular uptake of RNAi molecules remain considerable barriers to their efficient delivery which is paramount to a successful therapy. This book provides a comprehensive introduction to RNAi delivery, then goes on to discuss different delivery strategies, and concludes with current applications in various diseases. It covers: Mechanisms, Barriers, and Analysis of RNAi DeliveryNonclinical Safety Assessments and Clinical Pharmacokinetics: A Regulatory PerspectiveBioconjugation of siRNA for Site Specifi c DeliveryNanoscale Delivery Systems for RNAiEnvironmentally-Responsive Delivery Systems for RNAiLight-sensitive RNAiViral-Mediated Delivery of shRNA and miRNARNAi applications in Cancer Therapy, Liver Diseases, Hepatitis B, and Ocular DiseasemiRNA as therapeutic agents and targets Advanced Delivery and Therapeutic Applications of RNAi combines the essential aspects of developing RNAi therapeutics from bench to clinic, and is invaluable for researchers working on RNAi, drug discovery and delivery, biomedical engineering, biomaterials, molecular biology, and biotechnology. Content: Chapter 1 Mechanisms and Barriers to RNAi Delivery (pages 3–17): Jiehua Zhou and John J. Rossi Chapter 2 Analysis of siRNA Delivery Using Various Methodologies (pages 19–44): Yi Pei Chapter 3 Challenges and Opportunities in Bringing RNAi Technologies from Bench to Bed (pages 45–62): Sandesh Subramanya and Lance Ford Chapter 4 Nonclinical Safety Assessments and Clinical Pharmacokinetics for Oligonucleotide Therapeutics: A Regulatory Perspective (pages 63–81): Shwu?Luan Lee, Paul Brown, Jian Wang and Robert T. Dorsam Chapter 5 Role of Promoters and Micro RNA Backbone for Efficient Gene Silencing (pages 83–108): Feng Li and Ram I. Mahato Chapter 6 Bioconjugation of siRNA for Site?specific Delivery (pages 111–136): Bin Qin, Wei Jin and Kun Cheng Chapter 7 Multifunctional RNAi Delivery Systems (pages 137–161): China Malakondaiah Kummitha, Anthony S. Malamas and Zheng?Rong Lu Chapter 8 Dendrimers in RNAi Delivery (pages 163–185): Jose Luis Jimenez Fuentes, Paula Ortega, Sara Ferrando?Martinez, Rafael Gomez, Manuel Leal, Javier de la Mata and M?Angeles Munoz? Fernandez Chapter 9 Development of Pharmaceutically Adapted Mesoporous Silica Nanoparticles for siRNA Delivery (pages 187–205): Wilson X. Mai, Tian Xia and Huan Meng Chapter 10 Environmentally?Responsive Nanogels for siRNA Delivery (pages 207–224): Atsushi Tamura and Yukio Nagasaki Chapter 11 Viral?Mediated Delivery of shRNA and miRNA (pages 225–254): Fredric P. Manfredsson Chapter 12 The Control of RNA Interference with Light (pages 255–268): Simon H. Friedman Chapter 13 RNAi in Cancer Therapy (pages 271–307): Cristian Rodriguez?Aguayo, Arturo Chavez?Reyes, Gabriel Lopez?Berestein and Anil K. Sood Chapter 18 Adenovirus?mediated shRNA Delivery to Cancer (pages 309–326): Chae?Ok Yun Chapter 15 RNAi in Liver Diseases (pages 327–366): Jiang Li, Jianqin Lu, Yifei Zhang, Mohammed Ghazwani, Peng Zhang, Xiang Gao and Song Li Chapter 16 Approaches to Delivering RNAi Therapeutics that Target Hepatitis B Virus (pages 367–389): Carol Crowther, Mohube Betty Mowa, Abdullah Ely and Patrick Arbuthnot Chapter 17 RNAi in Respiratory Diseases (pages 391–416): Ciara Kelly, Awadh B. Yadav, Paul J. McKiernan, Catherine M. Greene and Sally?Ann Cryan Chapter 18 RNAi in Ocular Diseases (pages 417–437): Andrey Turchinovich, Georg Zoidl and Rolf Dermietzel Chapter 19 micro RNAs as Therapeutic Agents and Targets (pages 439–482): D.S. Karolina and K. Jeyaseelan Chapter 20 Delivery of Micro RNA Sponges for Interrogation of Micro RNA Function In Vitro and In Vivo (pages 483–504): Jiakai Lin and Shu Wang

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