Intracytoplasmic Sperm Injection: Indications, Techniques and Applications

Description

This unique, comprehensive text on the male factor infertility experience centers on the current background, applications and techniques for intracytoplasmic sperm injection (ICSI), one of the more commonly utilized procedures in modern assisted reproduction for male infertility, offering insights into the rationale and indications for ICSI and providing an up-to-date discussion on male factor diagnostic tests and microsurgical techniques for ICSI itself. Topics covered include the role of reproductive genetics, the effects of paternal age, the assessment, development and selection of functional human spermatozoa (e.g., Comet assay), both naturally and in the laboratory, and the procedures by which these sperm are injected directly into an oocyte. Comparisons are made between efficacy rates of ICSI versus conventional IVF strategies, and clinical approaches to fertilization failures following ICSI are presented, and intracytoplasmic morphologically selected sperm injection (IMSI) is discussed in detail in a chapter of its own. Bringing together the latest evidence and written by international leaders in the field, Intracytoplasmic Sperm Injection: Indications, Techniques and Applications is a unique and accessible resource for reproductive endocrinologists, andrologists, geneticists and infertility practitioners and researchers alike. Front Matter ....Pages i-xiii Male-Factor Infertility: Factoring in the Male Experience (Diederik F. Janssen)....Pages 1-8 Intracytoplasmic Sperm Injection: History, Indications, Technique, and Safety (Nigel Pereira, Gianpiero D. Palermo)....Pages 9-21 The Role of Reproductive Genetics in Modern Andrology (Douglas T. Carrell, Timothy G. Jenkins, Benjamin R. Emery, James M. Hotaling, Kenneth I. Aston)....Pages 23-38 Effect of Paternal Age on Reproductive Outcomes: Data from Intracytoplasmic Sperm Injection and Oocyte Donation (Lena Sagi-Dain, Martha Dirnfeld)....Pages 39-47 New Paradigms in De Novo Creation of Functional Human Spermatozoa: A Review of Biological Progress Towards Clinical Application (Nina Neuhaus, Tim Pock, Stefan Schlatt, Verena Nordhoff)....Pages 49-61 Assessment of Sperm DNA Integrity and Implications for the Outcome of ICSI Treatments (Preben Christensen, Anders Birck)....Pages 63-84 Sperm Evaluation Using the Comet Assay (Océane Albert, Bernard Robaire)....Pages 85-98 Automated Morphology Detection from Human Sperm Images (Seyed Abolghasem Mirroshandel, Fatemeh Ghasemian)....Pages 99-122 Clinical Approaches to Male Factor Infertility (Omer A. Raheem, Tung-Chin Hsieh)....Pages 123-141 Intracytoplasmic Morphologically Selected Sperm Injection (IMSI): An Overview (Daniel Luna Origgi, Javier García-Ferreyra)....Pages 143-155 Implications of Sperm Source on ICSI Outcome: Assessment of TESE and Other Surgical Sperm Retrieval Methods (Nikita Abhyankar, Samuel Ohlander, Martin Kathrins)....Pages 157-168 Intracytoplasmic Sperm Injection (ICSI): Applications and Insights (Toru Suzuki, Anthony C. F. Perry)....Pages 169-181 The Human Y-chromosome: Evolutionary Directions and Implications for the Future of “Maleness” (Darren K. Griffin, Peter J. I. Ellis)....Pages 183-192 Back Matter ....Pages 193-198