ENGLISH

Self and Nonself

By Jesús Martínez-Borra , Segundo González , Carlos López-Larrea (auth.) , Carlos López-Larrea PhD (eds.)

Book information

Publisher
Springer-Verlag New York
Year
2012
ISBN
9781461416807, 1461416809
DOI
10.1007/978-1-4614-1680-7
Language
english
Format
PDF
Filesize
4 MB (4648378 bytes)
Series
Advances in Experimental Medicine and Biology 738
Edition
1
Pages
318\338
Topic
Medicine immunology
Library
usenet tech
Time added
2013-03-30 20:00:00
Immunology; Biomedicine general

Description

In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.

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