Drug Transporters in Drug Disposition, Effects and Toxicity

Description

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field. Front Matter ....Pages i-x Overview: Role of Drug Transporters in Drug Disposition and Its Clinical Significance (Xiaodong Liu)....Pages 1-12 ABC Family Transporters (Xiaodong Liu)....Pages 13-100 SLC Family Transporters (Xiaodong Liu)....Pages 101-202 Current Research Method in Transporter Study (Dianlei Wang)....Pages 203-240 Transporter-Mediated Drug-Drug Interactions and Their Significance (Xiaodong Liu)....Pages 241-291 Roles of Hepatic Drug Transporters in Drug Disposition and Liver Toxicity (Guoyu Pan)....Pages 293-340 Roles of Renal Drug Transporter in Drug Disposition and Renal Toxicity (Xinning Yang, Li Han)....Pages 341-360 Intestinal Transporter-Associated Drug Absorption and Toxicity (Yaru Xue, Chenhui Ma, Imad Hanna, Guoyu Pan)....Pages 361-405 Contributions of Drug Transporters to Blood-Brain Barriers (Li Liu, Xiaodong Liu)....Pages 407-466 Roles of Drug Transporters in Blood-Retinal Barrier (Li Liu, Xiaodong Liu)....Pages 467-504 Contributions of Drug Transporters to Blood-Placental Barrier (Li Liu, Xiaodong Liu)....Pages 505-548 ABC Transporter-Mediated Multidrug-Resistant Cancer (Haneen Amawi, Hong-May Sim, Amit K. Tiwari, Suresh V. Ambudkar, Suneet Shukla)....Pages 549-580