Patient-derived xenograft models of human cancer

Description

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field. Read more... Abstract: This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field Front Matter ....Pages i-xi Patient-Derived Tumor Xenografts: Historical Background (Dong Lin, Xinya Wang, Peter W. Gout, Yuzhuo Wang)....Pages 1-9 Towards Best Practice in Establishing Patient-Derived Xenografts (Gail P. Risbridger, Mitchell G. Lawrence)....Pages 11-28 Fidelity and Stability of PDX Models (Gang Li)....Pages 29-42 Humanized Mouse and Rat PDX Cancer Models (Fallon K. Noto, Tseten Yeshi)....Pages 43-57 Studies of Cancer Heterogeneity Using PDX Models (Danyi Wen, Feifei Zhang, Yuan Long)....Pages 59-69 The Plasticity of Stem-Like States in Patient-Derived Tumor Xenografts (Alastair H. Davies, Fraser Johnson, Kirsi Ketola, Amina Zoubeidi)....Pages 71-91 Modeling Cancer Metastasis (Nora M. Navone, Estefania Labanca)....Pages 93-114 Modeling Drug Resistance in PDX Models (Erin L. Stewart, Ming Sound Tsao)....Pages 115-126 Using PDX for Biomarker Development (Werner J. Struss, Peter C. Black)....Pages 127-140 Patient-Derived Xenografts as Cancer Models for Preclinical Drug Screening (Juliet A. Williams)....Pages 141-154 First-Generation Tumor Xenografts: A Link Between Patient-Derived Xenograft Models and Clinical Disease (Xin Dong, Peter W. Gout, Lu Yi, Yinhuai Wang, Yong Xu, Kuo Yang)....Pages 155-176 Application of PDX Cancer Models in Co-clinical Trials and Personalized/Precision Medicine (Hongwei Cheng, Zongwen Liu, Hui Xue, Peter W. Gout, Hong Shan)....Pages 177-192 Prospectives (Dong Lin, Yuzhuo Wang, Peter W. Gout)....Pages 193-200 Back Matter ....Pages 201-204