ENGLISH

Protein Quality Control in Neurodegenerative Diseases

By Yves Christen (eds.) , Richard I. Morimoto , Eric Guisbert , Richard I. Morimoto (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2013
ISBN
978-3-642-27927-0, 978-3-642-27928-7
DOI
10.1007/978-3-642-27928-7
Language
english
Format
PDF
Filesize
2 MB (2053867 bytes)
Series
Research and Perspectives in Alzheimer's Disease
Edition
1
Pages
136\144
Orientation
yes
Scanned
yes
Time added
2013-10-26 00:35:21
Neurosciences; Neurochemistry; Molecular Medicine

Description

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

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