ENGLISH

p53 Suppressor Gene

By Tapas Mukhopadhyay Ph.D. , Steven A. Maxwell Ph.D. , Jack A. Roth M.D. (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1995
ISBN
978-3-662-22277-5, 978-3-662-22275-1
DOI
10.1007/978-3-662-22275-1
Language
english
Format
PDF
Filesize
4 MB (4302784 bytes)
Series
Molecular Biology Intelligence Unit
Edition
1
Pages
132\142
Time added
2013-12-12 02:00:00
Cancer Research; Molecular Medicine

Description

This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.

Similar books