ENGLISH

Targeted Interference with Signal Transduction Events

By Bernd Groner (auth.) , Professor Dr. Bernd Groner (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2007
ISBN
978-3-540-31208-6, 978-3-540-31209-3
DOI
10.1007/978-3-540-31209-3
Language
english
Format
PDF
Filesize
3 MB (3106252 bytes)
Series
Resent Results in Cancer Research 172
Edition
1
Pages
188\192
Orientation
yes
Scanned
yes
Time added
2013-10-22 01:23:37
Cancer Research; Oncology; Molecular Medicine

Description

Sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs. DNA mutations of a limited set of genes are responsible for the multiple stages of tumorigenesis and metastasis. Matching of therapeutic intervention with insights into the underlying molecular disease mechanism has led to the development of drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to extrapolate this principle and derive more efficient drugs targeting cancer pathway components? Potential drug targets have been identified, but our ability to predict the consequences of inhibition of such components is still limited. The state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities, is described in this book.

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