ENGLISH

The Physical Foundation of Protein Architecture

By Nobuhiko Saito , Yukio Kobayashi

Book information

Publisher
World Scientific
Year
2001
ISBN
9789810247102, 9810247109
LCC
QP551 .S32 2001
Open Library ID
OL3579780M
Language
english
Format
PDF
Filesize
5 MB (5760636 bytes)
Edition
1st
Pages
155\155
Topic
Physics
Time added
2010-02-18 13:16:04

Description

A protein requires its own three-dimensional structure for its biological activity. If a chemical agent is added, the biological activity is lost, and the three-dimensional structure is destroyed to become a random coil state. But when the chemical agent is removed, the biological activity is recovered, implying that the random coil state turns back into the original complex structure spontaneously. This is an astonishing event. "The Physical Foundation of Protein Architecture" is intended to solve this mystery from the physicochemical basis by elucidating the mechanism of various processes in protein folding. The main features of protein folding are shown to be described by the island model with long range hydrophobic interaction which is capable of finding the specific residue, and the lampshade criterion for disulfide bonding. Various proteins with known structure are refolded, with the purpose of uncovering the mechanism of protein folding. In addition, ab initio method for predicting protein structure from its amino acid sequence is proposed.

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