Hepatitis B Virus and Liver Disease

Description

This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in managem ent of patients with chronic HBV infection and investigation of HBV infection. Front Matter ....Pages i-xvii Molecular Virology and Life Cycle (Darren J. Wong, Stephen A. Locarnini)....Pages 1-23 Unmet Needs in Basic Research: In Vitro and In Vivo Models (Kazuaki Chayama, C. Nelson Hayes)....Pages 25-43 Immunopathogenesis of Hepatitis B Virus (HBV) Infection (Fu-Sheng Wang, Ji-Jing Shi)....Pages 45-62 Epidemiology and Natural History of Chronic Hepatitis B Virus Infection (Yael Bogler, Robert J. Wong, Robert G. Gish)....Pages 63-89 Hepatitis B Vaccines (John W. Ward, Pierre Van Damme)....Pages 91-117 Viral Factors Affecting Disease Progression (Hung-Chih Yang)....Pages 119-133 Hepatitis B Virus Genotype and Mutations Related to Clinical Outcome (Masaya Sugiyama, Tadasu Shin-I, Masashi Mizokami)....Pages 135-142 Molecular Carcinogenesis of HBV-Related HCC (Valerie Fako, Xin W. Wang)....Pages 143-162 Non-invasive Assessment of Liver Disease (Henry Lik-Yuen Chan, Vincent Wai-Sun Wong)....Pages 163-179 Chronic HBV Infection: Interferon Therapy and Long-Term Outcomes (Tarik Asselah, Patrick Marcellin)....Pages 181-191 Nucleos(t)ide Therapy and Long-Term Outcomes (Jonggi Choi, Young-Suk Lim)....Pages 193-217 Combination Therapy (Di Wu, Qin Ning)....Pages 219-237 Treatment of HCV, HDV, or HIV Coinfection (Carla S. Coffin, Norah A. Terrault)....Pages 239-262 Management of Chronic Hepatitis B Virus Infection in Children and Pregnant Women (Ming-Wei Lai, Huey-Ling Chen, Mei-Hwei Chang)....Pages 263-296 Occult Hepatitis B Infection (Man-Fung Yuen)....Pages 297-313 Hepatitis B Virus Reactivation and Management of Patients Undergoing Immunosuppression (Prowpanga Udompap, W. Ray Kim)....Pages 315-341 Exploring New Therapies for a Serological Cure of Chronic Hepatitis B (Jau-Hau Horng, Chang-Ru Wu, Pei-Jer Chen)....Pages 343-353 Back Matter ....Pages 355-360