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Cover; Series Introduction; Preface; About the Editors; Contributors; Contents; 1 Application of Nutrigenomics Tools to Analyze the Role of Oxidants and Antioxidants in Gene Expression; WHAT IS NUTRIGENOMICS?; DO OXIDANTS AND ANTIOXIDANTS AFFECT GENE EXPRESSION?; METHODS AND APPLICATIONS IN NUTRIGENOMICS; REFERENCES; 2 Oxidative Stress and Human Genetic Variation; MANGANESE SUPEROXIDE DISMUTASE; COPPER, ZINC SUPEROXIDE DISMUTASE; THE GLUTATHIONE-S-TRANSFERASES; THE GST GENES; GLUTATHIONE-S-TRANSFERASE T1; Functional Studies of the 894G> T (Glu298Asp) Polymorphism.;Application of Nutrigenomics Tools to Analyze the Role of Oxidants and Antioxidants in Gene Expression, Gerald Rimbach and Sonia De Pascual-TeresaOxidative Stress and Human Genetic Variation, R.D. Gill-Garrison, J.L. Slater, and K. GrimaldiAnalysis of Microarray Data, Ken MillsOxidative Stress, Gene Expression, and Lifespan, Yoko Honda and Shuji HondaAnti-Oxidant Modulation in Immune Function, Robert Francis GrimbleConcentration-Dependent Gene and Protein Expressions of Neuroprotective and Neurotoxic Activities of Antioxidants, Including Nutrients, Orly Weinreb, Silvia Mandel, and Moussa B. Cover Series Introduction Preface About the Editors Contributors Contents 1 Application of Nutrigenomics Tools to Analyze the Role of Oxidants and Antioxidants in Gene Expression WHAT IS NUTRIGENOMICS? DO OXIDANTS AND ANTIOXIDANTS AFFECT GENE EXPRESSION? METHODS AND APPLICATIONS IN NUTRIGENOMICS REFERENCES 2 Oxidative Stress and Human Genetic Variation MANGANESE SUPEROXIDE DISMUTASE COPPER, ZINC SUPEROXIDE DISMUTASE THE GLUTATHIONE-S-TRANSFERASES THE GST GENES GLUTATHIONE-S-TRANSFERASE T1 Functional Studies of the 894G&gt T (Glu298Asp) Polymorphism. Potential Dietary InterventionsCATALASE NADPH OXIDASE NADPH Oxidase Background NADPH Polymorphisms NADPH Polymorphisms and Health Conditions GLUTATHIONE PEROXIDASE MYELOPEROXIDASE NADPH DEHYDROGENASE, QUINONE 1 NADPH Background NADPH Polymorphisms CONCLUSION REFERENCES 3 Analysis of Microarray Data INTRODUCTION NORMALIZATION METHODS Per Array Normalization Per Gene Normalizations DATA ANALYSIS Fold Changes in Expression Levels Class Discovery-Unsupervised Learning Methods Class Prediction-Supervised Learning Methods VALIDATION OF MICROARRAY ANALYSIS. Laboratory Based ValidationMICROARRAY ANALYSIS SOFTWARE SUMMARY REFERENCES 4 Oxidative Stress, Gene Expression, and Lifespan INTRODUCTION LIFESPAN REGULATION IN C. ELEGANS Aging of C. elegans Stress, Hormesis, and Lifespan in C. elegans Insulin/IGF-I Signaling and Lifespan Regulation Insulin/IGF-I Signaling Pathway and Stress Resistance DAF-16 Transcription Target Reproductive System and Lifespan Nervous System and Lifespan Mitochondrial Electron Transport and Lifespan LIFESPAN REGULATION IN DROSOPHILA LIFESPAN REGULATION IN MAMMALS REPLICATIVE LIFESPAN AND OXIDATIVE STRESS. CONCLUSIONREFERENCES 5 Anti-Oxidant Modulation in Immune Function INTRODUCTION THE IMMUNE RESPONSE TO INFECTION INJURY AND INFLAMMATORY AGENTS THE FUNCTION OF PRO-INFLAMMATORY CYTOKINES DURING THE NORMAL RESPONSE TO INFECTION AND INJURY ADVERSE EFFECTS OF PRO-INFLAMMATORY CYTOKINES ANTI-OXIDANT DEFENSES ARE INTERLINKED AND INTERDEPENDENT A DECLINE IN ANTI-OXIDANT DEFENSES AND INCREASED OXIDANT DAMAGE FOLLOWS INFECTION AND INJURY AGING INCREASES OXIDATIVE AND INFLAMMATORY STRESS Mechanisms Underlying Low-Grade Inflammation During Aging. MECHANISMS OF THE EFFECTS OF OXIDANTS AND ANTI-OXIDANTS ON INFLAMMATION AND IMMUNE FUNCTIONEFFECTS OF ANTI-OXIDANTS ON IMMUNE FUNCTION Effects of Vitamin E Ascorbic Acid and Immune Function Glutathione and Immune Function EFFECTS OF SUBSTANCES THAT ACT AS PRECURSORS FOR GSH OR COFACTORS IN ENZYME PATHWAYS ASSOCIATED WITH GSH ON IMMUNE FUNCTION Effects of Precursors of GSH on Immune Function Effects of Vitamin B6 on Immune Function Effects of Folic Acid on Immune Function Taurine and Immune Function CONCLUSIONS REFERENCES.