Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions

Description

The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”. This volume, “Mechanisms and Models of Drug Interactions,” delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development. Front Matter ....Pages i-xvi Introduction to Drug-Drug Interactions (Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold)....Pages 1-13 Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion (David M. Burger, Lindsey H. M. te Brake, Rob E. Aarnoutse)....Pages 15-47 Mechanisms of Drug Interactions II: Transport Proteins (Darren Michael Moss, Marco Siccardi, Catia Marzolini)....Pages 49-85 Drug-Food Interactions (Eric Wenzler, Kelly Sprandel-Harris, Keith A. Rodvold)....Pages 87-162 Drug-Cytokine Interactions (Kerry B. Goralski, Matthew A. Ladda, Jenna O. McNeil)....Pages 163-204 Interactions Between Herbs and Anti-infective Medications (Surulivelrajan Mallayasamy, Scott R. Penzak)....Pages 205-242 In Vitro Modeling of Drug-Drug Interactions (Grant T. Generaux)....Pages 243-257 Probe Cocktail Studies (Anne N. Nafziger, Joseph S. Bertino Jr)....Pages 259-284 Design and Data Analysis in Drug Interaction Studies (David E. Nix, Keith Gallicano)....Pages 285-315 Back Matter ....Pages 317-326