Neurochemistry of the Vestibular System
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Description
The ability to quantify the sensory stimuli and resulting behavioral responses has enabled researchers over the past thirty years to gain an in-depth understanding of the physiological processes and neural pathways involved in the control of eye and head movements and posture. However, the molecular mechanisms and neurochemical processes that underlie neurotransmission of the vestibular and oculomotor pathways have begun to be defined only during the past decade. The first book available on this topic, Neurochemistry of the Vestibular System covers the proliferation of new information stemming from the technical advances in the areas of molecular biology and neurochemistry. It analyzes the recent developments in areas that relate to the neurochemical organization of the hair cells in the inner ear, the vestibular nerve, the vestibular nuclear complex, and central afferent and efferent vestibular projections. The book also identifies future directions for research in the areas of neurotransmitters, second messengers, transcription factors, and molecular mechanisms involved with both normal vestibular function and compensation. Features Cover Half Title Title Copyright Contents I. Perspectives 1. Overview of the Vestibular System: Anatomy II. Peripheral Vestibular Transmission 2. Vestibular Hair Cell-Afferent Transmission 3. Synaptic Transmission by Vestibular Nerve Afferent Fibers 4. Efferent Vestibular System: Anatomy, Physiology, and Neurochemistry III. Neurochemistry of the Vestibular Nuclear Complex 5. Excitatory Amino Acids and Nitric Oxide in the Vestibular Nuclei 6. Glutamatergic Transmission in the Medial Vestibular Nucleus 7. Inhibitory Amino Acid Transmitters in the Vestibular Nuclei 8. Modulatory Effects of Monoamines on Central Vestibular Neurons: Possible Functional Implications 9. Neuropeptides Associated with the Vestibular Nuclei IV. Neurochemical Mechanisms Underlying Vestibular Control of Movement and Posture 10. Neuropharmacological Aspects of the Vestibulo-Ocular Reflex 11. Control of Vestibulo-Spinal and Vestibulo-Ocular Reflexes by Noradrenergic and ACh Systems 12. Cholinergic Pathways and Functions Related to the Vestibulo-Cerebellum 13. Physiology and Ultrastructure of Unipolar Brush Cells in the Vestibulocerebellum V. Neurochemical Organization of Sensory Inputs to the Vestibular System 14. Neuronal Circuitry and Neurotransmitters in the Pretectal and Accessory Optic Systems 15. Somatosensory Influences on the Vestibular System 16. Chemical Comparisons between Centeral Vestibular and Auditory Systems VI. Neurochemical Basis of Plasticity and Adaptation 17. Immediate Early Gene Expression in the Vestibular System 18. The Contributions of Excitatory and Inhibitory Amino Acid Neurotransmitters to Vestibular Plasticity VII. Summary: 19. General Concepts and Principles Index
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