Notch signaling : immunity and cancer

Description

This book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch regulates many steps of immune cell differentiation or development as well as tumorigenesis of cells. Although there are still many controversial issues regarding the functions or regulatory mechanism of Notch, it is important to summarize all data together in one volume to help facilitate this research area. Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Therefore, this book covering the broad area of Notch in immunology and tumorigenesis will be attractive to many researchers including faculty members and postdoctoral fellows in academia and researchers in the pharmaceutical industry. Read more... Abstract: Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Read more... Front Matter ....Pages i-vii Front Matter ....Pages 1-1 Notch Ligands for Lymphocyte Development (Katsuto Hozumi)....Pages 3-20 Notch Controls the Differentiation and Function of Cytotoxic CD8 T Cells (Yoichi Maekawa, Takahide Ikeda, Piyarat Srinontong)....Pages 21-33 Notch and Myeloid Cells (Chieko Ishifune, Koji Yasutomo)....Pages 35-55 Taking CD4 T Cells Up a Notch (Christina Helbig, Derk Amsen)....Pages 57-75 Front Matter ....Pages 77-77 NOTCH in Malignant Lymphoma (Shigeru Chiba)....Pages 79-92 The Two Faces of Notch in Solid Cancers (Craig S. Nowell, Freddy Radtke)....Pages 93-104