ENGLISH

An Introduction to Smooth Muscle Mechanics

By Chun Y. Seow

Book information

Publisher
Cambridge Scholars Publishing
Year
2021
ISBN
1527560732, 9781527560734
Language
english
Format
PDF
Filesize
11 MB (11242842 bytes)
Edition
2
Pages
189\190
Time added
2022-04-12 13:54:04

Description

This second edition is an updated version of an introductory level textbook intended for students who are interested in understanding the mechanical properties of smooth muscle. Compared with skeletal and cardiac muscles, smooth muscle is the least understood in terms of its contraction mechanism and the structure of its contractile apparatus. Nevertheless, it is an important tissue that is vital in many organ functions, such as blood pressure control, intestinal peristalsis, and the emptying of the bladder. Dysfunction of the muscle has been implicated in many diseases such as high blood pressure, asthma, and overactive bladders. This is the only book-length treatment of functional models of a variety of smooth muscle behaviors with their corresponding mathematical descriptions, and offers an easy-to-follow, step-by-step mathematical derivation that will help students to appreciate the muscle cell as a fine-tuned aggregate of mechanisms governed by the fundamental laws of physics. In addition to providing a detailed description of the known subcellular structure and mechanical function of the contractile apparatus of smooth muscle, it also covers experimentation techniques, instrumentation, and data analysis. The book is a must-have information source for anyone interested in smooth muscle cell ultrastructure, physiology, biochemistry, and pharmacology. Dedication Contents Preface List of Symbols 1. Introduction 2. Structural Basis of Smooth Muscle Contraction 3. Basic Muscle Mechanics 4. The Actomyosin Cross-bridge Cycle 5. Force-Velocity Relationship 6. Length-Force Relationship and Length Adaptation 7. Instrumental Analysis of Force and Length Measurements Appendix IA: PSS for intact muscle preparations Appendix IB: PSS for skinned muscle preparations Appendix II: Exact mathematical solution for cyclic matrix of any size References Glossary Subject Index

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