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Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.* Reviews the application of quantitative and mathematical methods towards understanding chemical problems* Multidisciplinary volumes cover organic, organometallic, bioorganic, enzymes and materials topics. Read more... Content: Cover; Advances in Physical Organic Chemistry; Copyright Page; Contents; Editor's Preface; Volume 41-Advances in Physical Organic Chemistry; Contributors to Volume 41; The interpretation and mechanistic significance of activation volumes for organometallic reactions; Introduction: basic principles and theory; Experimental; Volumes of activation for thermal organometallic reactions; Volumes of activation for radiation-induced organometallic reactions; Concluding remarks; Acknowledgements; References. Calculation of kopt from optical data using adiabatic theoryBJ treatment for ET within IV compounds; Effects of low-bridge-oxidized excitation energies; Acknowledgements; References; Using kinetic isotope effects to determine the structure of the transition states of SN2 reactions; Theory of kinetic isotope effects; Using KIEs to determine how substituents, the solvent, ion pairing and enzymes affect the structure of the SN2 transition state; Acknowledgment; References; Mechanisms for nucleophilic aliphatic substitution at glycosides; Scope and rationale for this review. Introduction and general pointsKey experimental methods; Studies of glucosides; Studies of deoxyglucosides; Studies of N-acetyl neuraminic acids; Substituent effects on glycoside reactivity; Pyranosyl oxocarbenium ion conformations and reactivity; Computational analyses of oxocarbenium ion reactions; Mechanistic studies of ''synthetic'' reactions and glycon donors; Experimental gas-phase studies; Conclusions; Acknowledgments; References; Effect of enzyme dynamics on catalytic activity; Introduction; Proton transfer and rate-promoting vibrations. Examples of rate-promoting motions in enzymatic systemsDescription in atomic detail of correlated protein motions; Conformational fluctuations; References; Cumulative Index of Authors; Cumulative Index of Titles; Subject Index. Abstract: Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.* Reviews the application of quantitative and mathematical methods towards understanding chemical problems* Multidisciplinary volumes cover organic, organometallic, bioorganic, enzymes and materials topics