Tumors of the Central Nervous System, Volume 2: Gliomas: Glioblastoma (Part 2)

Description

Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained. Front Matter....Pages i-xxi Introduction....Pages 1-7 Front Matter....Pages 9-9 Gliomagenesis: Advantages and Limitations of Biomarkers....Pages 11-24 Molecular Subtypes of Gliomas....Pages 25-29 Glioblastoma: Germline Mutation of TP53 ....Pages 31-38 Familial Gliomas: Role of TP53 Gene....Pages 39-45 The Role of IDH1 and IDH2 Mutations in Malignant Gliomas....Pages 47-52 Malignant Glioma: Isocitrate Dehydrogenases 1 and 2 Mutations....Pages 53-62 Metabolic Differences in Different Regions of Glioma Samples....Pages 63-72 Glioblastoma Patients: Role of Methylated MGMT....Pages 73-79 Brain Tumor Angiogenesis and Glioma Grading: Role of Tumor Blood Volume and Permeability Estimates Using Perfusion CT....Pages 81-91 Vasculogenic Mimicry in Glioma....Pages 93-101 Newly Diagnosed Glioma: Diagnosis Using Positron Emission Tomography with Methionine and Fluorothymidine....Pages 103-112 Role of Diffusion Tensor Imaging in Differentiation of Glioblastomas from Solitary Brain Metastases....Pages 113-121 131 I-TM-601 SPECT imaging of Human Glioma....Pages 123-130 Assessment of Biological Target Volume Using Positron Emission Tomography in High-Grade Glioma Patients....Pages 131-141 Skin Metastases of Glioblastoma....Pages 143-149 Front Matter....Pages 151-151 Diffuse Low-Grade Gliomas: What Does “Complete Resection” Mean?....Pages 153-161 Quantitative Approach of the Natural Course of Diffuse Low-Grade Gliomas....Pages 163-172 Impact of Extent of Resection on Outcomes in Patients with High-Grade Gliomas....Pages 173-179 Glioma Surgery: Intraoperative Low Field Magnetic Resonance Imaging....Pages 181-187 Front Matter....Pages 151-151 Low-Grade Gliomas: Intraoperative Electrical Stimulations....Pages 189-205 Malignant Gliomas: Present and Future Therapeutic Drugs....Pages 207-214 Recurrent Malignant Glioma Patients: Treatment with Conformal Radiotherapy and Systemic Therapy....Pages 215-227 Glioblastoma: Boron Neutron Capture Therapy....Pages 229-239 Glioblastoma: Anti-tumor Action of Cyclosporin A and Functionally Related Drugs....Pages 241-253 Glioblastoma Patients: Chemotherapy with Cisplatin, Temozolomide and Thalidomide....Pages 255-260 Glioblastoma: Role of Galectin-1 in Chemoresistance....Pages 261-267 Glioma-Initiating Cells: Interferon Treatment....Pages 269-276 Glioblastoma: Anti-tumor Action of Natural and Synthetic Cannabinoids....Pages 277-287 Patients with Recurrent High-Grade Glioma: Therapy with Combination of Bevacizumab and Irinotecan....Pages 289-299 Monitoring Gliomas In Vivo Using Diffusion-Weighted MRI During Gene Therapy-Induced Apoptosis....Pages 301-311 High-Grade Gliomas: Dendritic Cell Therapy....Pages 313-333 Glioblastoma Multiforme: Use of Adenoviral Vectors....Pages 335-347 Fischer/F98 Glioma Model: Methodology....Pages 349-359 Cellular and Molecular Characterization of Anti-VEGF and IL-6 Therapy in Experimental Glioma....Pages 361-369 Adult Brainstem Gliomas: Diagnosis and Treatment....Pages 371-377 The Use of Low Molecular Weight Heparin in the Treatment and Prevention of Thromboembolic Disease in Glioma Patients....Pages 379-384 Front Matter....Pages 385-385 Brainstem Gliomas: An Overview....Pages 387-395 Tumor-Associated Epilepsy in Patients with Glioma....Pages 397-406 Brain Tumors Arising in the Setting of Chronic Epilepsy....Pages 407-416 Front Matter....Pages 385-385 Low-Grade Gliomas: Role of Relative Cerebral Blood Volume in Malignant Transformation....Pages 417-423 Angiocentric Glioma-Induced Seizures: Lesionectomy....Pages 425-434 Back Matter....Pages 435-458