ENGLISH

Drug Targeting: Strategies, Principles, and Applications

By G. E. Francis

Book information

Publisher
Humana Press
Year
2000
ISBN
9780585395098, 9780896035317, 089603531X
Open Library ID
OL9618645M
Language
english
Format
PDF
Filesize
2 MB (1681219 bytes)
Edition
1
Pages
299\299
Library
mexmat
Time added
2009-07-20 03:45:11

Description

G. E. Francis and Cristina Delgado have assembled a comprehensive collection of leading-edge protocols for drug targeting studies. In addition to the detailed step-by-step instruction, the protocols review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also present are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, and the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium. Comprehensive and innovative, Drug Targeting: Strategies, Principles, and Applications documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals.

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