Click Chemistry for Biotechnology and Materials Science

Description

Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology.  The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions. Content: Chapter 1 Click Chemistry: A Universal Ligation Strategy for Biotechnology and Materials Science (pages 1–7): Joerg LahannChapter 2 Common Synthons for Click Chemistry in Biotechnology (pages 9–28): Christine Schilling, Nicole Jung and Stefan BraseChapter 3 Copper?Free Click Chemistry (pages 29–51): Jeremy M. Baskin and Carolyn R. BertozziChapter 4 Protein and Peptide Conjugation to Polymers and Surfaces Using Oxime Chemistry (pages 53–68): Heather D. Maynard, Rebecca M. Broyer and Christopher M. KolodziejChapter 5 The Role of Click Chemistry in Polymer Synthesis (pages 69–88): Jean?Francois Lutz and Brent S. SumerlinChapter 6 Blocks, Stars and Combs: Complex Macromolecular Architecture Polymers via Click Chemistry (pages 89–117): Sebastian Sinnwell, Andrew J. Inglis, Martina H. Stenzel and Christopher Barner?KowollikChapter 7 Click Chemistry on Supramolecular Materials (pages 119–175): Wolfgang H. Binder and Robert SachsenhoferChapter 8 Dendrimer Synthesis and Functionalization by Click Chemistry for Biomedical Applications (pages 177–193): Daniel Q. McNerny, Douglas G. Mullen, Istvan J. Majoros, Mark M. Banaszak Holl and James R. BakerChapter 9 Reversible Diels–Alder Cycloaddition for the Design of Multifunctional Network Polymers (pages 195–215): Amy M. Peterson and Giuseppe R. PalmeseChapter 10 Click Chemistry in the Preparation of Biohybrid Materials (pages 217–254): Heather J. Kitto, Jan Lauko, Floris P. J. T. Rutjes and Alan E. RowanChapter 11 Functional Nanomaterials using the Cu?Catalyzed Huisgen Cycloaddition Reaction (pages 255–289): Sander S. van Berkel, Arnold W. G. Nijhuis, Dennis W. P. M. Lowik and Jan C. M. van HestChapter 12 Copper?Catalyzed ‘Click’ Chemistry for Surface Engineering (pages 291–307): Himabindu Nandivada and Joerg LahannChapter 13 Click Chemistry in Protein Engineering, Design, Detection and Profiling (pages 309–325): Daniela C. Dieterich and A. James LinkChapter 14 Fluorogenic Copper(I)?Catalyzed Azide–Alkyne Cycloaddition Reactions and their Applications in Bioconjugation (pages 327–353): Celine Le Droumaguet and Qian WangChapter 15 Synthesis and Functionalization of Biomolecules via Click Chemistry (pages 355–378): Christine Schilling, Nicole Jung and Stefan BraseChapter 16 Unprecedented Electro?Optic Properties in Polymers and Dendrimers Enabled by Click Chemistry Based on the Diels–Alder Reactions (pages 379–398): Jingdong Luo, Tae?Dong Kim and Alex K.?Y. Jen