Gestational Trophoblastic Disease: Diagnostic and Molecular Genetic Pathology

Description

In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations. Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students. Front Matter....Pages i-xiii Gestational Trophoblastic Disease: General Aspects....Pages 1-14 Developmental Biology of the Placenta....Pages 15-39 Genetic Basis of Gestational Trophoblastic Disease....Pages 41-55 Complete Hydatidiform Mole....Pages 57-75 Partial Hydatidiform Mole....Pages 77-90 Placental Site Trophoblastic Tumor....Pages 91-103 Epithelioid Trophoblastic Tumor....Pages 105-125 Gestational Choriocarcinoma....Pages 127-137 Persistent Trophoblastic Neoplasia....Pages 139-145 Tumor-Like Trophoblastic Conditions....Pages 147-159 Molecular Diagnosis of Gestational Trophoblastic Disease....Pages 161-178 Clinical Aspects of Gestational Trophoblastic Disease....Pages 179-194 Back Matter....Pages 195-205