Core-Shell Nanostructures for Drug Delivery and Theranostics : Challenges, Strategies and Prospects for Novel Carrier Systems

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Content: Front Cover Core-Shell Nanostructures for Drug Delivery and Theranostics Copyright Page Contents List of Contributors I. Fundamentals on Nanotechnology for Drug Delivery 1 Introduction to "Core-shell nanostructures for drug delivery and theranostics: Challenges, strategies, and prospects for ... 2 Physicochemical properties of nanosized polymeric drug carrier systems 2.1 Introduction 2.2 Polymeric nanocarrier systems 2.2.1 Polymer NPs (nanospheres, nanocapsules, and micelles) 2.2.2 Liposomes 2.2.3 Dendrimers 2.3 Main therapeutic agents encapsulated 2.3.1 Anticancer drugs 2.4 Physical properties2.4.1 Dimension and surface charge 2.4.2 Physical state 2.5 Chemical properties 2.5.1 Hydrophobicity/hydrophilicity 2.5.2 Molecular weight 2.6 Conclusion References 3 Biomineralization process generating hybrid nano- and micro-carriers 3.1 Introduction 3.2 Biomineralization 3.3 Magnetic materials in medicine 3.4 Intrinsically magnetic and hybrid nanobeads as carriers in nanomedicine 3.5 Intrinsically magnetic hybrid microspheres as smart release systems 3.6 Interaction between cells and biomimetic magnetic carriers 3.7 Conclusion and future trends AcknowledgmentReferences 4 Clinical applications of nanostructured drug delivery systems: from basic research to translational medicine 4.1 Introduction 4.2 Organic vs. inorganic NDS 4.2.1 Organic NDS 4.2.1.1 Liposomes 4.2.1.2 Micelles/PMs 4.2.1.3 Lipid NPs 4.2.1.4 Polymeric NPs 4.2.1.5 Protein NPs 4.2.2 Inorganic NDS 4.2.2.1 Iron oxide NPs 4.2.2.2 Mesoporous silica NPs 4.2.2.3 Gold NPs 4.2.2.4 Quantum dots NPs 4.3 Application of NDS in different therapeutic areas 4.3.1 Oncology 4.3.2 Disorders of the central nervous system 4.3.3 Disorders of the immune system 4.4 Problems associated to translational nanomedicine4.5 Conclusions Acknowledgments References II. Core-Shell Nanoparticles 5 Core-shell nanoparticles and their use for in vitro and in vivo diagnostics 5.1 Introduction 5.2 Synthesis of core-shell NPs 5.2.1 Shell synthesis on preformed cores 5.2.1.1 Sol-gel approach 5.2.1.2 Coprecipitation 5.2.1.3 Metal reduction 5.2.1.4 Polymerization 5.2.1.5 Physical routes 5.2.2 Droplet-based microfluidic approach 5.2.3 LBL technique 5.3 Applications 5.3.1 In vivo diagnostics/medical imaging 5.3.2 In vitro applications 5.4 Conclusion and future trendsReferences 6 Core-shell nanoparticles for cancer imaging and therapy 6.1 Introduction 6.2 Bioimaging 6.2.1 Core-shell NPs for MRI 6.2.1.1 SPIO-based core-shell NPs 6.2.1.2 Paramagnetic Gd3+ and Mn2+-based core-shell NPs 6.2.2 Core-shell NPs for FL imaging 6.2.2.1 Quantum dots 6.2.2.2 Lanthanide-doped NPs 6.2.2.3 Other core-shell NPs 6.2.3 Core-shell NPs for CT 6.2.4 Core-shell NPs for multimodal imaging 6.3 Therapy 6.3.1 Photothermal therapy 6.3.1.1 Au NPs for PTT Au nanocages and nanorods Au nanoshell 6.3.1.2 Other core-shell NPs for in PTT