ENGLISH

Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation (Progress in Inflammation Research)

By AB Malmberg & KR Bley (Eds.)

Book information

Year
2005
ISBN
3764370807, 9783764370800, 9783764373795
LCC
QP451.4 .T87 2005
Open Library ID
OL3424952M
Language
english
Format
PDF
Filesize
2 MB (1746589 bytes)
Edition
1
Pages
261\248
Scanned
yes
Time added
2011-06-04 13:46:07

Description

Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by capsaicin and related vanilloids, TRPV1 responds to heat and extracellular acidification, and will integrate simultaneous exposures to these stimuli. The aim of this book is to summarize recent insights in the role of TRPV1 in pain and inflammation, and to discuss how modulation of this receptor may lead to important advances in analgesic drug development. Insights into the prospects for the therapeutic potential of TRPV1 activation or inhibition, particularly in various painful or inflammatory conditions, are provided. The volume is written for basic scientists and clinicians interested in the mechanisms of pain, inflammation and the treatment of these conditions.

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