Mathematical Modeling of Protein Complexes

Description

This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins. The models also take the phosphorylation of amino acid residues into account. At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine. Front Matter ....Pages i-xiv Physical Methods for Studying Proteins (Tatiana Koshlan, Kirill Kulikov)....Pages 1-12 Mathematical Simulation of Complex Formation of Protein Molecules Allowing for Their Domain Structure (Tatiana Koshlan, Kirill Kulikov)....Pages 13-54 Mathematical Modelling of the Temperature Effect on the Character of Linking Between Monomeric Proteins in Aqueous Solutions (Tatiana Koshlan, Kirill Kulikov)....Pages 55-131 Mathematical Modelling of the Effect of a Monovalent Salt Solution on the Interaction of Protein Molecules (Tatiana Koshlan, Kirill Kulikov)....Pages 133-168 Mathematical Modeling Identification of Active Sites Interaction of Protein Molecules (Tatiana Koshlan, Kirill Kulikov)....Pages 169-262 Mathematical Modelling of the Effect of Phosphorylation on the Stability of the Formation of Biological Complexes P53–Mdm2 and P53–P300 (Tatiana Koshlan, Kirill Kulikov)....Pages 263-289 Mathematical Modelling of the Interaction of BH3-Peptides with Full-Length Proteins, and Account of the Influence of Point Mutations on the Stability of the Formed Biological Complex on the Example of the Bcl-2 Family Proteins (Tatiana Koshlan, Kirill Kulikov)....Pages 291-308 Mathematical Algorithms for Finding the Optimal Composition of the Amino Acid Composition of Peptides Used as a Therapy (Tatiana Koshlan, Kirill Kulikov)....Pages 309-363 Back Matter ....Pages 365-367