Biomarkers of the tumor microenvironment : basic studies and practical applications
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This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors. Read more... Abstract: Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors. Read more... Front Matter ....Pages i-xvii Front Matter ....Pages 1-1 The Role of the Tumor Microenvironment in Regulating Angiogenesis (Randolph S. Watnick)....Pages 3-23 More Than a Barrier: How the Endothelium Instructs Metastasis (Candice Alexandra Grzelak, Andrea Rachel Lim, Cyrus Michael Ghajar)....Pages 25-53 Tissue-Based Biomarkers of Tumor-Vascular Interactions (Lars A. Akslen)....Pages 55-75 Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support? (Cédric Zeltz, Roya Navab, Marion Kusche-Gullberg, Ming-Sound Tsao, Donald Gullberg)....Pages 77-112 Stromal PDGF Receptors as Prognostic and Predictive Biomarkers (Arne Östman)....Pages 113-128 The Function and Diagnostic Potential of Adipocyte-Derived Factors in the Tumor Microenvironment (Joan Chang, Andrew C. Dudley)....Pages 129-166 Inflammation and Cancer: The Role of Lipid Signaling in the Continuum Between Two Ends of the Tumor Spectrum (Megan L. Sulciner, Molly M. Gilligan, Bruce R. Zetter, Dipak Panigrahy)....Pages 167-193 Cancer Immunity and Immune Evasion Mechanisms (Stalin Chellappa, Einar M. Aandahl, Kjetil Taskén)....Pages 195-220 Drivers of EMT and Immune Evasion (Rolf A. Brekken, Katarzyna Wnuk-Lipinska)....Pages 221-239 Inflammatory Biomarkers for Cancer (Alexandre Corthay, Guttorm Haraldsen)....Pages 241-257 Immunology of Solid Tumors Beyond Tumor-Infiltrating Lymphocytes: The Role of Tertiary Lymphoid Structures (Gert G. G. M. Van den Eynden, Roberto Salgado, Karen Willard-Gallo)....Pages 259-280 The Role of Platelets in the Tumor Microenvironment (Kelly E. Johnson, Sandra S. McAllister, Joseph E. Italiano Jr., Elisabeth M. Battinelli)....Pages 281-302 Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments (Tina El Rayes, Dingcheng Gao, Nasser K. Altorki, Thomas R. Cox, Janine T. Erler, Vivek Mittal)....Pages 303-328 Neuropilin 1 and Neuropilin 2: Cancer Progression and Biomarker Analysis (Xiaoran Li, Diane R. Bielenberg)....Pages 329-349 The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance (Kjersti T. Davidsen, Gry S. Haaland, Maria K. Lie, James B. Lorens, Agnete S. T. Engelsen)....Pages 351-376 Front Matter ....Pages 377-377 Gene Expression Signatures of the Tumor Microenvironment: Relation to Tumor Progress in Breast Cancer (Elisabeth Wik, Lars A. Akslen)....Pages 379-407 MR-Derived Biomarkers for Cancer Characterization (Eugene Kim, Morteza Esmaeili, Siver A. Moestue, Tone F. Bathen)....Pages 409-431 The Influence of Tissue Architecture on Drug Response: Anticancer Drug Development in High-Dimensional Combinatorial Microenvironment Platforms (Chun-Han Lin, Mark A. LaBarge)....Pages 433-447 Models of Tumor Progression in Prostate Cancer (Waqas Azeem, Yaping Hua, Karl-Henning Kalland, Xisong Ke, Jan Roger Olsen, Anne Margrete Øyan et al.)....Pages 449-464 Tumor-Host Interactions in Malignant Gliomas (Lina Leiss, Ercan Mutlu, Mohummad Aminur Rahman, Per Øyvind Enger)....Pages 465-479 The Tumor Microenvironment in Cutaneous Melanoma: Friend or Foe (Oddbjørn Straume, Cornelia Schuster)....Pages 481-506 Biomarker Panels and Contemporary Practice in Clinical Trials of Targeted Therapy (Nina Louise Jebsen, Samantha Scarlett, Bergrun Tinna Magnusdottir, Bjørn Tore Gjertsen)....Pages 507-523 Back Matter ....Pages 525-534
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