Skin Aging & Cancer: Ambient UV-R Exposure

Description

This book summarizes the potent effect of ultraviolet radiation (UVR) on the photoaging and cancer formation. Skin is the largest human organ which continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. This protection can be compromised by the aging of the skin which ultimately promotes skin inflammation, impaired wound repair, and increased risk of skin cancer. The book entails mechanistic insights into the UVR-induced immunomodulation and DNA damage in the skin to delineate the pathogenesis, and develop novel ways for prevention of photoaging of the skin cells. It also elucidates the potential of nanotechnology in the treatment of skin cancer. Further, it discusses the bioinformatics approaches to understand the molecular mechanism of photoaging and cancer formation. Front Matter ....Pages i-xvii Skin Anatomy and Morphology (Neera Yadav, Shama Parveen, Shilpa Chakravarty, Monisha Banerjee)....Pages 1-10 Understanding Cellular and Molecular Events of Skin Aging and Cancer: An Integrative Perspective (Bhupender Singh, Himani Malhotra, Dhruv Kumar, Syed Faiz Mujtaba, Atul Kumar Upadhyay)....Pages 11-28 Human Skin Stem Cells, Aging, and Possible Antiaging Strategies (Shambhoo Sharan Tripathi, Sandeep Singh, Abhishek Kumar Singh)....Pages 29-40 UVR-Induced Skin Cancer (Jyoti Singh)....Pages 41-46 Ultraviolet Radiation-Induced Immunomodulation: Skin Ageing and Cancer (Garima Suman, Shankar Suman)....Pages 47-58 UVR and Role of Pigmentation in Skin Aging and Cancer (Neeraj Agarwal)....Pages 59-69 UVR and Vitamin D Synthesis (Deepti Chopra, Dhanananajay Kumar, Divya Dubey, Jyoti Singh, Ajeet Kumar Srivastav, Kailash Chand Gupta)....Pages 71-78 Chemiexcitation of Melanin and Melanoma Pathogenesis (Saroj Kumar Amar, Dhanananajay Kumar)....Pages 79-86 Future Prospective of Nanotechnology in Skin Cancer Therapeutics (Lipika Ray)....Pages 87-100 Bioinformatics in Skin Cancer: A System Biology Approach to Understanding the Molecular Mechanisms and It’s Regulations (Manish Kumar Tripathi, Jitendera Sinha, Sushant Kumar Srivastava, Dhruv Kumar)....Pages 101-111 UV-R Interaction with Skin: Cases of Study (Gonzalo Gurrea Ysasi)....Pages 113-127 Monitoring the Genotoxic Potential of Sunlight and DNA Photoprotection of Sunscreen (James Eduardo Lago Londero, André Passaglia Schuch)....Pages 129-143