ENGLISH

Checkpoint Controls and Targets in Cancer Therapy

By Krijn K. Dijkstra , Cristophe Blanchetot , Johannes Boonstra (auth.) , Zahid H. Siddik (eds.)

Book information

Publisher
Humana Press
Year
2009
ISBN
1607611775, 9781607611776
DOI
10.1007/978-1-60761-178-3
LCC
QP552.G76 C44 2010
Open Library ID
OL25040986M
Language
english
Format
PDF
Filesize
6 MB (6801924 bytes)
Series
Cancer Drug Discovery and Development
Edition
1
Pages
274\276
Topic
Medicine Oncology
Time added
2011-06-04 13:46:07
Cancer Research; Oncology; Pharmacology/Toxicology

Description

There is no question that loss of cell cycle checkpoint regulation is an intrinsic characteristic of cancer. However, many tumors retain parallel checkpoint pathways that are activated by antitumor agents and facilitate therapeutic response. Failures in these therapy-linked checkpoint controls are closely associated with cancers that are highly resistant to therapeutic interventions. Checkpoint Controls and Targets in Cancer provides present-day mechanistic understandings of how multiple sets of proteins orchestrate cell cycle progression, discusses critical checkpoint controls that are evaded for cancer development, focuses on checkpoint pathways associated with antitumor effects, and identifies specific checkpoint regulators for targeting with small molecules in the clinical management of cancer. These aspects of cell cycle checkpoints are articulated critically by renowned experts from both academia and industry, and new concepts are forwarded that challenge existing dogmas. Collectively, Checkpoint Controls and Targets in Cancer provides a unique collection of insightful contributions, which are timely and offer significant interest and appeal to basic, translational and clinical scientists.

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