Marks' Basic Medical Biochemistry: A Clinical Approach

Description

Selected as a Doody's Core Title for 2021! Connect biochemistry to clinical practice!" Marks’ Basic Medical Biochemistry links biochemistry to physiology and pathophysiology, allowing students to apply fundamental concepts to the practice of medicine – from diagnosing patients to recommending effective treatments. Intuitively organized chapters center on hypothetical patient vignettes, highlighting the material’s clinical applications; helpful icons allow for smooth navigation, making complex concepts easier to grasp. Full-color illustrations make chemical structures and biochemical pathways easy to visualize. Patient vignettes connect biochemistry to human health and disease. Clinical Notes explain patient signs or symptoms, and Method Notes relate biochemistry to the laboratory tests ordered during diagnosis.Clinical Comments link biochemical dynamics to treatment options and patient outcomes.Biochemical Comments explore directions for new research.Key Concepts and Summary Disease tables highlight the take-home messages in each chapter. Questions and answers at the end of each chapter – 470 total inside the book, with 560 more online – probe students’ mastery of key concepts. Additional handy resources available online make it easy to review all diseases and all methods covered throughout the book and to find references for further information and study Cover Title Copyright Preface to the 5th Edition How to Use This Book Acknowledgments Contents SECTION I Fuel Metabolism 1 Metabolic Fuels and Dietary Components 2 The Fed or Absorptive State 3 Fasting SECTION II Chemical and Biologic Foundations of Biochemistry 4 Water, Acids, Bases, and Buffers 5 Structures of the Major Compounds of the Body 6 Amino Acids in Proteins 7 Structure-Function Relationships in Proteins 8 Enzymes as Catalysts 9 Regulation of Enzymes 10 Relationship between Cell Biology and Biochemistry 11 Cell Signaling by Chemical Messengers SECTION Ill Gene Expression and the Synthesis of Proteins 12 Structure of the Nucleic Acids 13 Synthesis of DNA 14 Transcription: Synthesis of RNA 15 Translation: Synthesis of Proteins 16 Regulation of Gene Expression 17 Use of Recombinant DNA Techniques in Medicine 18 The Molecular Biology of Cancer SECTION IV Carbohydrate Metabolism, Fuel Oxidation, and the Generation of Adenosine Triphosphate 19 Basic Concepts in the Regulation of Fuel Metabolism by Insulin, Glucagon, and Other Hormones 20 Cellular Bioenergetics: Adenosine Triphosphate and O2 21 Digestion, Absorption, and Transport of Carbohydrates 22 Generation of Adenosine Triphosphate from Glucose, Fructose, and Galactose: Glycolysis 23 Tricarboxylic Acid Cycle 24 Oxidative Phosphorylation and Mitochondrial Function 25 Oxygen Toxicity and Free-Radical Injury 26 Formation and Degradation of Glycogen 27 Pentose Phosphate Pathway and the Synthesis of Glycosides, Lactose, Glycoproteins, and Glycolipids 28 Gluconeogenesis and Maintenance of Blood Glucose Levels SECTION V Lipid Metabolism 29 Digestion and Transport of Dietary Lipids 30 Oxidation of Fatty Acids and Ketone Bodies 31 Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane Lipids 32 Cholesterol Absorption, Synthesis, Metabolism, and Fate 33 Metabolism of Ethanol 34 Integration of Carbohydrate and Lipid Metabolism SECTION VI Nitrogen Metabolism 35 Protein Digestion and Amino Acid Absorption 36 Fate of Amino Acid Nitrogen: Urea Cycle 37 Synthesis and Degradation of Amino Acids 38 Tetrahydrofolate,Vitamin B12, and S-Adenosylmethionine 39 Purine and Pyrimidine Metabolism 40 lntertissue Relationships in the Metabolism of Amino Acids SECTION VII Tissue Metabolism 41 Actions of Hormones that Regulate Fuel Metabolism 42 The Biochemistry of Erythrocytes and Other Blood Cells 43 Blood Plasma Proteins, Coagulation, and Fibrinolysis 44 Liver Metabolism 45 Metabolism of Muscle at Rest and during Exercise 46 Metabolism of the Nervous System 47 The Extracellular Matrix and Connective Tissue Patient Index Subject Index A B C D E F G H I J K L M N O P Q R S T U V W X Y Z