Cytogenetics and Molecular Cytogenetics

Description

Genomic technologies provide the means of diagnosis and management of many human diseases. Without insights from cytogenetics, correct interpretation of modern high-throughput results is difficult, if not impossible. This book summarizes applications of cytogenetics and molecular cytogenetics for students, clinicians and researchers in genetics, genomics and diagnostics. The book combines the state-of-the-art knowledge and practical expertise from leading researchers and clinicians and provides a comprehensive overview of current medical and research applications of many of these technologies. KEY FEATURES • Provides clear summaries of fluorescence in situ hybridization technologies and others • Comprehensively covers established and emerging methods • Chapters from an international team of leading researchers • Useful for students, researchers and clinicians Cover Half Title Series Title Copyright Dedication Contents Series Preface Preface Acknowledgements Editor List of Contributors Chapter 1 Cytogenetics and Chromosomics Chapter 2 Banding Cytogenetics Chapter 3 Generation of Microdissection-Derived Painting Probes from Single Copy Chromosomes Chapter 4 FISH—An Overview Chapter 5 FISH—Microscopy and Evaluation Chapter 6 FISH—in Routine Diagnostic Settings Chapter 7 FISH—in Leukemia Diagnostics Chapter 8 FISH—in Tissues Chapter 9 FISH—in Human Sperm and Infertility Chapter 10 FISH—in Spontaneously Aborted Products of Conception Chapter 11 FISH—Characterization of Chromosomal Alterations, Recombination, and Outcomes after Segregation Chapter 12 Multicolor-FISH—Methods and Applications Chapter 13 FISH—Centromere- and Heterochromatin-Specific Multicolor Probe Sets Chapter 14 FISH—Detection of Individual Radio Sensitivity Chapter 15 FISH—Detection of CNVs Chapter 16 FISH—Interphase Applications Including Detection of Chromosome Instability (CIN) Chapter 17 FISH—Determination of Telomere Length (Q-FISH/CO-FISH) Chapter 18 FISH—in Three Dimensions—3D-FISH Chapter 19 FISH—On Fibers Chapter 20 FISH—and Single-Cell Gel Electrophoresis Assay (Comet Assay) Chapter 21 Molecular Karyotyping Chapter 22 FISH—Mitochondrial DNA Chapter 23 FISH—in Birds Chapter 24 FISH—in Fish Chromosomes Chapter 25 FISH—and the Characterization of Synaptonemal Complex Chapter 26 RNA-FISH—on Lampbrush Chromosomes: Visualization of Individual Transcription Units Chapter 27 FISH—in Insect Chromosomes Chapter 28 FISH—in Plant Chromosomes Chapter 29 FISH—and CRISPR/CAS9 Index