ENGLISH

HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design: A Review of 20 Years of Research

By Marc H V Van Regenmortel

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-030-32458-2, 978-3-030-32459-9
Language
english
Format
PDF
Filesize
5 MB (5538738 bytes)
Edition
1st ed. 2019
Pages
XXVII, 364\379
Time added
2020-02-08 04:42:00
Biomedicine; Vaccine; Virology

Description

This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments. Front Matter ....Pages i-xxvii Front Matter ....Pages 1-1 What Is a B Cell Epitope (Marc H V Van Regenmortel)....Pages 3-15 Molecular Design Versus Empirical Discovery in Peptide-Based Vaccines: Coming to Terms with Fuzzy Recognition Sites and Ill-Defined Structure-Function Relationships in Immunology (Marc H V Van Regenmortel)....Pages 17-24 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes (Marc H V Van Regenmortel)....Pages 25-37 Specificity, Polyspecificity and Heterospecificity of Antibody-Antigen Recognition (Marc H V Van Regenmortel)....Pages 39-56 Front Matter ....Pages 57-57 Reductionism and the Search for Structure: Function Relationships in Antibody Molecules (Marc H V Van Regenmortel)....Pages 59-70 Reductionism and Complexity in Molecular Biology: Scientists Now Have the Tools to Unravel Biological Complexity and Overcome the Limitations of Reductionism (Marc H V Van Regenmortel)....Pages 71-78 Editorial: Biological Complexity Emerges from the Ashes of Genetic Reductionism (Marc H V Van Regenmortel)....Pages 79-86 The Rational Design of Biological Complexity: A Deceptive Metaphor (Marc H V Van Regenmortel)....Pages 87-102 Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking (Marc H V Van Regenmortel)....Pages 103-126 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking (Marc H V Van Regenmortel)....Pages 127-129 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases (Marc H V Van Regenmortel)....Pages 131-140 Front Matter ....Pages 141-141 Limitations to the Structure-Based Design of HIV-1 Vaccine Immunogens (Marc H V Van Regenmortel)....Pages 143-159 Two Meanings of Reverse Vaccinology and the Empirical Nature of Vaccine Science (Marc H V Van Regenmortel)....Pages 161-162 Requirements for Empirical Immunogenicity Trials, Rather than Structure-Based Design, for Developing an Effective HIV Vaccine (Marc H V Van Regenmortel)....Pages 163-188 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013 (Marc H V Van Regenmortel)....Pages 189-197 Editorial: Paradigm Changes Are Required in HIV Vaccine Research (Marc H V Van Regenmortel)....Pages 199-203 An Outdated Notion of Antibody Specificity Is One of the Major Detrimental Assumptions of the Structure-Based Reverse Vaccinology Paradigm, Which Prevented It from Helping to Develop an Effective HIV-1 Vaccine (Marc H V Van Regenmortel)....Pages 205-216 More Surprises in the Development of an HIV Vaccine (General Commentary) (Marc H V Van Regenmortel)....Pages 217-220 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 Not Inform the Rational Design of an HIV-1 Vaccine? (Marc H V Van Regenmortel)....Pages 221-228 Old and New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop Held in Rome on 17 June 2016 (Marc H V Van Regenmortel)....Pages 229-248 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because It Disregarded Accepted Immunological Theory (Marc H V Van Regenmortel)....Pages 249-277 Immune Systems Rather than Antigenic Epitopes Elicit and Produce Protective Antibodies Against HIV (Marc H V Van Regenmortel)....Pages 279-281 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design (Marc H V Van Regenmortel)....Pages 283-298 Viral Species, Viral Genomes and HIV Vaccine Design: Is the Rational Design of Biological Complexity a Utopia? (Marc H V Van Regenmortel)....Pages 299-310 Back Matter ....Pages 311-364

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