Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease

Description

Ketogenic diets have treated epilepsy for nearly 100 years, yet metabolic therapy has remained obscure and underutilized for most of this time. In recent decades, the clinical efficacy of ketogenic therapy was confirmed definitively for pediatric epilepsy and has now expanded to adult epilepsy. Now, the benefits of metabolic therapy have been extended well beyond epilepsy to additional neurological, metabolic, and genetic disorders, and the importance of metabolic health is recognized as paramount. This new edition of Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease highlights the growing research and clinical applications of metabolic therapies as effective in disease treatment, reversal and prevention. Emerging mechanisms include the landscape of the microbiome and epigenetics. Consistent with the first observations in 1921, in some cases metabolism-based strategies have proven equal or superior to pharmacological treatments for specific diseases and for treating multiple comorbidities. This second edition commemorates the 100th anniversary of the ketogenic diet, shares new research in this rapidly moving field, and offers a valuable collection of high-resolution color figures. The team of editors for this edition have been working in this area for decades, and in this volume, they have assembled world leaders in this cutting-edge research. As the first academic, interdisciplinary book on ketogenic diet and metabolic therapy, this volume will be crucial during this time of increased appreciation for metabolic health in professionals and the public alike. Contents Contributors 1. The 100th Anniversary of the Ketogenic Diet: Local and Global Perspectives SECTION I: KETOGENIC DIET FOR EPILEPSY IN THE CLINIC 2. Overview: Ketogenic Diets and Pediatric Epilepsy: An Update • Eric Kossoff 3. Alternative Ketogenic Diets • Elizabeth Neal 4. Ketogenic Diet Therapies in Adults: History, Demand, and Results • Emily L . Johnson and Mackenzie C. Cervenka 5. How Do You Implement the Diet? • A. G. Christina Bergqvist 6. GLUT1 Deficiency Syndrome and the Ketogenic Dietary Therapies • Joerg Klepper 7. Ketogenic Diet in Established Epilepsy Indications • Ann M. Bergin 8. Ketogenic Diet for Other Epilepsies • David T. Hsieh and Elizabeth A. Thiele 9. The Ketogenic Diets in Genetic Generalized Epilepsy Syndromes • Sudha Kilaru Kessler 10. Ketogenic Diet Therapy for Infants • Elles J . T. M. van der Louw, Stéphane Auvin, and J. Helen Cross 11. Ketogenic Diet in Status Epilepticus • Rima Nabbout 12. Preventing Side Effects and Diet Discontinuation • Cherie L. Herren and Rana R. Said SECTION II: KETOGENIC DIET: EMERGING CLINICAL APPLICATIONS AND FUTURE POTENTIAL 13. Overview: Expanded Uses of Ketogenic Therapies • Jong M. Rho 14. Metabolism-Based Treatments for Managing Cancer: Scientific Rationale • Thomas N. Seyfried, Purna Mukherjee, and Christos Chinopoulos 15. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer • Adrienne C. Scheck and Nelofer Syed 16. Ketogenic Diet, Social Behavior, and Autism: Insights from Animal Models • Ning Cheng, Susan A. Masino, and Jong M. Rho 17. Ketotherapeutics to Rescue Brain Energy Deficits: An Emerging Strategy to Delay Cognitive Decline in Alzheimer’s Disease • Étienne Myette-Côté, Christian-Alexandre Castellano, Mélanie Fortier, Valérie St-Pierre, and Stephen C. Cunnane 18. Ketogenic Diet and Ketones for Improving Neurologic Outcomes after Acute Neurotrauma • Oscar Seira, Kathleen L. Kolehmainen, Ward T. Plunet, Ceren Yarar- Fisher, and Wolfram Tetzlaff 19. Ketogenic Diets and Neuroinflammation • David Ruskin, Nina Dupuis, and Stéphane Auvin 20. The Ketogenic Diet in the Treatment of Schizophrenia • Zoltán Sarnyai, Ann-Katrin Kraeuter, and Christopher M. Palmer 21. The Ketogenic Diet and the Gut Microbiome • Chunlong Mu, Jane Shearer, Morris H. Scantlebury, and Wendie N. Marks SECTION III: KETOGENIC DIET IN THE LABORATORY 22. Overview: Ketogenic Diet in the Laboratory: Progress on Models and Mechanisms • Detlev Boison 23. Ketogenic Diet and PPARγ • Timothy A. Simeone 24. Ketogenic Diet and Adenosine in Epilepsy: Models and Mechanisms • Masahito Kawamura Jr. 25. Ketogenic Diet and Epigenetic Mechanisms of Epileptogenesis • Madhuvika Murugan, Fabio C. Tescarollo, and Detlev Boison 26. Ketogenic Diet, Aging, and Neurodegeneration • Kui Xu, Aarti Sethuraman, Joseph C. Lamanna, and Michelle A. Puchowicz 27. Metabolic Seizure Resistance via BAD and KATP Channels • Juan Ramón Martínez-François, Nika Danial, and Gary Yellen 28. Lactate Dehydrogenase: A Novel Metabolic Target • Nagisa Sada and Tsuyoshi Inoue 29. Effects of the Ketogenic Diet on the Blood–Brain Barrier • Dami R. Janigro 30. Metabolic and Redox Alterations by Ketogenic Diets • Derek Johnson and Manisha Patel 31. Nicotinamide Adenine Dinucleot ideas a Central Mediator of Ketogenic Therapy • Marwa Elamin, David N. Ruskin, Susan A. Masino, and Paola Sacchetti SECTION IV: KETONE-BASED METABOLISM: GENERAL HEALTH AND METABOLIC ALTERNATIVES 32. Overview: Ketone-Based Metabolism—General Health and Metabolic Alternatives • Dominic P. D’Agostino 33. Ketone Supplementation for Health and Disease 34. Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-Evoked Ketosis 35. Amino Acids in the Treatment of Neurologic Disorders 36. Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet • Angela M. Poff, Shannon L. Kesl, Andrew P. Koutnik, Sara E. Moss, Christopher Q. Rogers, and 37. Triheptanoin in Epilepsy and Beyond • Karin Borges 38. Antiseizure and Antiepileptic Effects of Glycolysis Inhibition with 2-Deoxyglucose • Carl E. Stafstrom, Li-Rong Shao, and Thomas P. Sutula 39. Low-Carbohydrate, Ketogenic Diets for the Treatment of Type 2 Diabetes and Obesity • Eric C. Westman, Justin Tondt, and William S. Yancy, Jr. 40. Intermittent Exogenous Ketosis for Athletic Performance, Recovery, and Adaptation • Brianna J. Stubbs and Peter Hespel 41. Advancing the Awareness and Application of Ketogenic Therapies Globally: The Charlie Foundation for Ketogenic Therapies and Matthew’s Friends • Beth Zupec-Kania, Jim Abrahams, Emma Williams, Susan A. Masino, and Jong M. Rho Index