Cold Plasma Cancer Therapy

Description

Cold atmospheric plasma (CAP) emerges as a possible new modality for cancer treatment. This book provides a comprehensive introduction into fundamentals of the CAP and plasma devices used in plasma medicine. An analysis of the mechanisms of plasma interaction with cancer and normal cells including description of possible mechanisms of plasma selectivity is included. Recent advances in the field, the primary challenges and future directions are presented. PRELIMS.pdf Acknowledgements Author biographies Michael Keidar Dayun Yan Jonathan H Sherman CH001.pdf Chapter 1 Plasma as a fourth state of matter 1.1 Plasma types References CH002.pdf Chapter 2 Introduction to the non-thermal plasmas References CH003.pdf Chapter 3 The anti-cancer effect of cold atmospheric plasma in vitro 3.1 The research status 3.2 The specific vulnerability of cancer cells to cap 3.3 The long-term cellular responses 3.4 The selective anti-cancer effect 3.5 The short-term cellular respones References CH004.pdf Chapter 4 The anti-cancer mechanism of cold atmospheric plasma in vitro 4.1 The activation of cancer cells 4.2 The reactive species 4.3 The rise of intracellular ROS 4.4 The selective anti-cancer mechanism References CH005.pdf Chapter 5 The anti-cancer effect of CAP treatment in vivo 5.1 Introduction 5.2 The in vivo demonstration 5.3 The clinical demonstration 5.4 Mechanism 5.5 Reactive species and skin References CH006.pdf Chapter 6 Indirect CAP treamtent, the application of the cold atmospheric plasma-activated solutions in cancer treatment 6.1 Introduction 6.2 The CAP-activated medium 6.3 The reactive species in PAS 6.4 The principles to make PAS References CH007.pdf Chapter 7 Adaptive plasmas and recent progress in plasma application in cancer therapy 7.1 Plasma self-organization phenomena 7.2 Adaptive plasma devices 7.3 MPC-based adaptive plasma platform References CH008.pdf Chapter 8 Clinical applications of cold atmospheric plasma for glioblastoma 8.1 Introduction 8.2 Cold atmospheric plasma as a potential mediator of immune stimulation Glioblastoma-mediated suppression of the systemic and local immune system Current immunotherapy approaches in the treatment of GBM Cold-activated plasma’s role in immunotherapy 8.3 Cold atmospheric plasma-mediated inflammation as a promoter of mesenchymal stem cell localization Mesenchymal stem cells and the tumor microenvironment Cold atmospheric plasma inflammation as a mediator of mesenchymal stem cell recruitment Cold atmospheric plasma and miR-MSC adjuvant therapy in the treatment of glioblastoma 8.4 Cold atmospheric plasma and nanoparticles applied as a synergistic cancer therapy Nanoparticles and the tumor microenvironment Cold atmospheric plasma with platinum nanoparticle adjunct therapy Cold atmospheric plasma with gold nanoparticle adjunct therapy The future of cold atmospheric plasma and nanoparticle adjunct therapy 8.5 Facing forward: cold atmospheric plasma treatment of glioblastoma Acknowledgements References