Thymus Transcriptome and Cell Biology
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Description
This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases. Front Matter ....Pages i-xvii History of the Thymus: From a Vestigial Organ to the Programming of Immunological Self-Tolerance (Vincent Geenen, Wilson Savino)....Pages 1-18 Thymus Ontogeny and Development (J. J. Muñoz, A. G. Zapata)....Pages 19-34 The Ins and Outs of Thymic Epithelial Cell Differentiation and Function (Minoru Matsumoto, Pedro M. Rodrigues, Laura Sousa, Koichi Tsuneyama, Mitsuru Matsumoto, Nuno L. Alves)....Pages 35-65 T-Cell Development: From T-Lineage Specification to Intrathymic Maturation (Kogulan Yoganathan, Edward L. Y. Chen, Jastaranpreet Singh, Juan Carlos Zúñiga-Pflücker)....Pages 67-115 Intrathymic Cell Migration: Implications in Thymocyte Development and T-Cell Repertoire Formation (Daniella Arêas Mendes-da-Cruz, Carolina Valença Messias, Julia Pereira Lemos, Wilson Savino)....Pages 117-148 Thymic Crosstalk: An Overview of the Complex Cellular Interactions That Control the Establishment of T-Cell Tolerance (Magali Irla)....Pages 149-167 The Autoimmune Regulator (AIRE) Gene, the Master Activator of Self-Antigen Expression in the Thymus (Matthieu Giraud, Pärt Peterson)....Pages 169-189 Aire Mutations and Autoimmune Diseases (Anette S. B. Wolff, Bergithe E. Oftedal)....Pages 191-214 The Thymus as a Mirror of the Body’s Gene Expression (Geraldo A. Passos, Adriana B. Genari, Amanda F. Assis, Ana C. Monteleone-Cassiano, Eduardo A. Donadi, Ernna H. Oliveira et al.)....Pages 215-234 Functional Genomics of the Infant Human Thymus: AIRE and Minipuberty (Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Fernanda Bernardi Bertonha, Magda Carneiro-Sampaio)....Pages 235-245 Thymus Transcriptome of TGF-β Superfamily (Arnon Dias Jurberg, Vinicius Cotta-de-Almeida)....Pages 247-254 Development of Thymic Regulatory T Lymphocytes (Larissa Vasconcelos-Fontes, Rafaella Ferreira-Reis, João Ramalho Ortigão-Farias, Arnon Dias Jurberg, Vinicius Cotta-de-Almeida)....Pages 255-272 Adding Insult to Injury: Improving the Regenerative Capacity of the Aged Thymus Following Clinically Induced Damage (Jarrod Dudakov, Michael L. Hun, Kahlia Wong, Georg Holländer, Ann P. Chidgey)....Pages 273-294 Thymus Rejuvenation After Autologous Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Diseases (João R. Lima-Júnior, Lucas C. M. Arruda, Maria Carolina de Oliveira, Kelen C. R. Malmegrim)....Pages 295-309 Back Matter ....Pages 311-318
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