ENGLISH

Myocardial Preconditioning

By PhD , FRCPath (auth.) , FRSE , FESC , Cherry L. Wainwright BSc , James R. Parratt PhD , MD DSchc

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1996
ISBN
978-3-662-22208-9, 978-3-662-22206-5
DOI
10.1007/978-3-662-22206-5
Language
english
Format
PDF
Filesize
12 MB (12230942 bytes)
Series
Medical Intelligence Unit
Edition
1
Pages
285\296
Time added
2014-01-18 08:00:00
Cell Biology

Description

This book is about the unique ability of the heart to protect itself against the serious consequences of an abrupt reduction in blood flow to the myocardium - a phenomenon which is switched on by stress and termed myocardial preconditioning. This volume describes the main features and characteristics of preconditioning, with respect to the time-course of the protective effect of the phenomenon (first and second windows) and the different sequelae of myocardial ischaemia against which it protects, such as myocardial injury, arrhythmias and contractile dysfunction. The proposed mechanisms underlying the fascinating form of cardioprotection are discussed. Among these are the role of endogenous labile mediators, receptor-linked G proteins, ATP-sensitive potassium channels and protein kinase C activation.

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