Membrane Organization and Dynamics

Description

This volume brings together information on membrane organization and dynamics from a variety of spectroscopic, microscopic and simulation approaches, spanning a broad range of time scales. The implication of such dynamic information on membrane function in health and disease is a topic of contemporary interest. The chapters cover various aspects of membrane lipid and protein dynamics, explored using a battery of experimental and theoretical approaches. The synthesis of information and knowledge gained by utilizing multiple approaches will provide the reader with a comprehensive understanding of the underlying membrane dynamics and function, which will help to develop robust dynamic models for the understanding of membrane function in healthy and diseased states. In the last few years, crystal structures of an impressive number of membrane proteins have been reported, thanks to tremendous advances in membrane protein crystallization techniques. Some of these recently solved structures belong to the G protein-coupled receptor (GPCR) family, which are particularly difficult to crystallize due to their intrinsic flexibility. Nonetheless, these static structures do not provide the necessary information to understand the function of membrane proteins in the complex membrane milieu. This volume will address the dynamic nature of membrane proteins within the membrane and will provide the reader with an up-to date overview of the theory and practical approaches that can be used. This volume will be invaluable to researchers working in a wide range of scientific areas, from biochemistry and molecular biology to biophysics and protein science. Students of these fields will also find this volume very useful. This book will also be of great use to those who are interested in the dynamic nature of biological processes. Front Matter ....Pages i-ix What Is So Unique About Biomembrane Organization and Dynamics? (Sreetama Pal, Amitabha Chattopadhyay)....Pages 1-9 Dynamics and Organization of Archaeal Tetraether Lipid Membranes (Parkson Lee-Gau Chong, Alexander Bonanno, Umme Ayesa)....Pages 11-30 Effects of Oxidative Stress, Hyperglycemia, and Hypercholesterolemia on Membrane Structural Organization and the Interactions of Omega-3 Fatty Acids (R. Preston Mason, Robert F. Jacob)....Pages 31-47 Interaction of Amphiphilic Molecules with Lipid Bilayers: Kinetics of Insertion, Desorption and Translocation (Hugo A. L. Filipe, Renato M. S. Cardoso, Luís M. S. Loura, Maria João Moreno)....Pages 49-89 Multidimensional Microscopy: Application to Membrane Protein Structure (Andrew H. A. Clayton)....Pages 91-111 Investigating the Dynamics and Organization of Membrane Proteins and Lipids by Imaging Fluorescence Correlation Spectroscopy (Nirmalya Bag, Shuangru Huang, Thorsten Wohland)....Pages 113-145 Probing Membrane Heterogeneity with k-space Image Correlation Spectroscopy (Elvis Pandzic, Paul W. Wiseman)....Pages 147-165 Determining Oligomerization of Membrane Proteins by Single Molecule Methods (Andreas Anderluh, Anand Kant Das, Gerhard J. Schütz)....Pages 167-193 Spatiotemporal Dynamics of Nicotinic Acetylcholine Receptors and Lipid Platforms (Francisco J. Barrantes)....Pages 195-217 Dynamics of Membrane Proteins (Sahil Lall, M. K. Mathew)....Pages 219-241 G-Protein-Coupled Receptors: Membrane Diffusion and Organization Matter (Evert Haanappel, Laurence Salomé)....Pages 243-258 Role of Membrane Microdomains in Serotonin Receptor Functions (Josephine Labus, Alexander Wirth, Andre Zeug, Evgeni Ponimaskin)....Pages 259-286 Rotation of Single Cell Surface Receptors Examined by Quantum Dot Probes (Dongmei Zhang, Peter W. Winter, Deborah A. Roess, B. George Barisas)....Pages 287-309 Combining NMR Spectroscopy and Molecular Dynamics Simulation to Investigate the Structure and Dynamics of Membrane-Associated Proteins (Alexander Vogel, Daniel Huster)....Pages 311-350 Computer Simulations of Membrane Proteins (Christian Jorgensen, Victoria Oakes, Carmen Domene)....Pages 351-374 Hydrophobic Mismatch in Membranes: When the Tail Matters (Bhagyashree D. Rao, Sandeep Shrivastava, Amitabha Chattopadhyay)....Pages 375-387