Allergy Frontiers: Classification and Pathomechanisms

Description

When I entered the field of allergy in the early 1970s, the standard textbook was a few hundred pages, and the specialty was so compact that texts were often authored entirely by a single individual and were never larger than one volume. Compare this with Allergy Frontiers: Epigenetics, Allergens, and Risk Factors, the present s- volume text with well over 150 contributors from throughout the world. This book captures the explosive growth of our specialty since the single-author textbooks referred to above. The unprecedented format of this work lies in its meticulous attention to detail yet comprehensive scope. For example, great detail is seen in manuscripts dealing with topics such as “Exosomes, naturally occurring minimal antigen presenting units” and “Neuropeptide S receptor 1 (NPSR1), an asthma susceptibility gene.” The scope is exemplified by the unique approach to disease entities normally dealt with in a single chapter in most texts. For example, anaphylaxis, a topic u- ally confined to one chapter in most textbooks, is given five chapters in Allergy Frontiers. This approach allows the text to employ multiple contributors for a single topic, giving the reader the advantage of being introduced to more than one vi- point regarding a single disease. Front Matter....Pages i-xxii Basic Aspects of Allergy and Hypersensitivity Reactions....Pages 3-17 Pathogen Recognition and New Insights into Innate Immunity....Pages 19-30 New Nomenclature and Clinical Aspects of Allergic Diseases....Pages 31-42 IgE and the High-Affinity Receptor, FcεRI: The IgE-CD23 Interaction....Pages 43-57 Superantigens and Allergic Disease....Pages 59-77 Immune Complexes: Normal Physiology and Role in Disease....Pages 79-94 What Is New About Eosinophil Activation in Asthma and Allergic Disease....Pages 95-107 Mast Cell and Basophils: Interaction with IgE and Responses to Toll like Receptor Activators....Pages 113-133 T Cells in Allergic Disease....Pages 135-149 Role of NKT Cells in the Regulation of Ongoing Type 2 Immune Response....Pages 151-165 CD8+ T Cells Play a Key Role in the Development of Allergic Lung Inflammation....Pages 167-178 Neutrophils and Their Mediators in Asthma and Allergic Disease....Pages 179-193 Dendritic Cells, Macrophages and Monocytes in Allergic Disease....Pages 195-207 Function of Dendritic Cell Subsets in Allergic Disease....Pages 209-230 Epithelial Cell-Mesenchymal Interaction, Epithelial-Leukocyte Interaction and Epithelial Immune-Response Genes in Allergic Disease....Pages 231-248 Role of Epidermal Growth Factor Receptor Cascade in Airway Epithelial Regulation of Mucus Production....Pages 249-265 Epithelial Cell Innate Responses to Rhinovirus Infection....Pages 267-284 The Role of Platelets in Allergy....Pages 285-296 Expression and Function of Siglec-8 in Human Eosinophils, Basophils, and Mast Cells....Pages 297-313 Effects of Nitric Oxide on Mast Cells: Production, Functions, and Mechanisms of Action....Pages 315-327 Histamine and Its Receptors....Pages 329-356 Adenosine: Its Contribution to Our Understanding in Airway Inflammation....Pages 357-376 Airway Smooth Muscle Dysfunction in Asthma....Pages 377-400 Genetic Variation in Cytokines, Asthma, and Atopy: The Role of IL-4/IL-13 Pathway Polymorphisms....Pages 401-419 Allergy and the Bone Marrow: Transmigration Pathways of Hemopoietic Progenitor Cells from the Bone Marrow....Pages 421-432 Hemopoietic Mechanisms in Allergic Rhinitis and Asthma....Pages 433-453 Neuroanatomy of the Airways....Pages 457-468 Biology of Neurotrophins, Neuropeptides, and Muscarinic Receptors in Asthma....Pages 469-491 Neural Regulation of the Immune Response....Pages 493-514 Neuroregulation of Mucosal Vasculature....Pages 515-526 Mucosal Immunity: from Allergy to Coeliac Disease....Pages 529-561 Mucosa-Associated Lymphoid Tissue and Dynamics of Lymphoid Cells in the Five Different Compartments in Allergic Diseases....Pages 563-601 Back Matter....Pages 603-606