ENGLISH

Immunotherapy of Sarcoma

By Sandra P. D'Angelo , Seth M. Pollack

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-319-93529-4, 978-3-319-93530-0
Language
english
Format
PDF
Filesize
3 MB (2803687 bytes)
Edition
1st ed.
Pages
VII, 152\150
Time added
2019-01-12 07:48:44
Medicine & Public Health; Oncology; Immunology

Description

This book describes recent progress in the development of immunotherapies for advanced sarcoma, paying special attention to the potential role of manipulations of the sarcoma tumor immune microenvironment in improving patient outcomes. Readers will find a thorough overview of the state of the art in tumor immunology and immunotherapy as they relate to sarcoma. Among the topics addressed are advances in vaccine therapy; cytokine therapies; natural killer cells; the development of adoptive T cell strategies; and the scope for use of checkpoint inhibitors in patients with sarcoma, mirroring the tremendous breakthroughs made in other malignancies. Detailed information is provided on laboratory and clinical research, with analysis of outcomes of recent trials and identification of key challenges. There is every reason to believe that more effective and less toxic therapies for metastatic sarcoma can be attained by deepening our understanding of cancer immunology and building on the advances in immunotherapy for other solid tumors. In this context, Immunotherapy of Sarcoma will be of high interest for all medical oncologists responsible for the treatment of sarcoma patients. Front Matter ....Pages i-vii Front Matter ....Pages 1-1 Role and Therapeutic Implications of MDSCs in Sarcomas (Brittany Lala, Anusha Kalbasi, Arun S. Singh)....Pages 3-15 Immune Response and Immunotherapy in GIST (Gerardo A. Vitiello, Benjamin D. Medina, Ronald P. DeMatteo)....Pages 17-31 Regulatory T cells (Vaia Florou, Breelyn A. Wilky)....Pages 33-45 Radiation and Immunotherapy for Sarcoma (Amy J. Wisdom, Yvonne M. Mowery, David G. Kirsch)....Pages 47-65 Front Matter ....Pages 67-67 Oncolytic Virus Immunotherapy in Sarcoma (Varun Monga, Seth M. Maliske, Mohammed Milhem)....Pages 69-116 Vaccine Therapy in Sarcoma (Swathi Namburi, Melissa Burgess)....Pages 117-123 Immune Checkpoint Inhibitors in Sarcoma (Sandra P. D’Angelo, Ciara M. Kelly)....Pages 125-137 Cellular Immunotherapy for Sarcomas (Seth M. Pollack, Georgios Antoniou)....Pages 139-152

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